Preeclampsia: long-term consequences for vascular health
TLDR
There is no “cure” for PE except for early delivery of the baby and placenta, leaving PE a health care risk for babies born from PE moms and a risk factor for long-term health in women.Abstract:
Preeclampsia (PE) is a pregnancy-specific syndrome and one of the leading causes of preterm birth, neonatal and maternal morbidity and mortality. This disease is characterized by new onset hypertension usually in the third trimester of pregnancy and is sometimes associated with proteinuria, although proteinuria is not a requirement for the diagnosis of PE. In developing countries, women have a higher risk of death due to PE than more affluent countries and one of the most frequent causes of death is high blood pressure and stroke. Although PE only affects approximately 2%-8% of pregnancies worldwide it is associated with severe complications such as eclampsia, hemorrhagic stroke, hemolysis, elevated liver enzymes and low platelets (HELLP syndrome), renal failure and pulmonary edema. Importantly, there is no "cure" for the disease except for early delivery of the baby and placenta, leaving PE a health care risk for babies born from PE moms. In addition, PE is linked to the development of cardiovascular disease and stroke in women after reproductive age, leaving PE a risk factor for long-term health in women. This review will highlight factors implicated in the pathophysiology of PE that may contribute to long-term effects in women with preeclamptic pregnancies.read more
Citations
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Preeclampsia: Updates in Pathogenesis, Definitions, and Guidelines
TL;DR: The shift has been made to view preeclampsia as a systemic disease with widespread endothelial damage and the potential to affect future cardiovascular diseases rather than a self-limited occurrence.
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Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review
TL;DR: The association between uric acid (UA) and systemic hypertension (Htn), dyslipidemia, glucose intolerance, overweight, fatty liver, renal disease and cardiovascular disease (CVD) on the other side is well recognized as discussed by the authors.
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All-Cause and Cause-Specific Mortality After Hypertensive Disease of Pregnancy.
Lauren Theilen,Alison Fraser,Michael S. Hollingshaus,Karen C. Schliep,Michael W. Varner,Ken R. Smith,M. Sean Esplin +6 more
TL;DR: Women with hypertensive disease of pregnancy have increased mortality risk, particularly for Alzheimer disease, diabetes, ischemic heart disease, and stroke.
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Pre-eclampsia and risk of dementia later in life: nationwide cohort study
TL;DR: Pre-eclampsia was associated with an increased risk of dementia, particularly vascular dementia, and Cardiovascular disease, hypertension, and diabetes were unlikely to mediate the associations substantially, suggesting that pre-eClampsia and vascular dementia may share underlying mechanisms or susceptibility pathways.
Journal ArticleDOI
Role of Mitochondrial Dysfunction and Reactive Oxygen Species in Mediating Hypertension in the Reduced Uterine Perfusion Pressure Rat Model of Preeclampsia.
Venkata Ramana Vaka,Kristen M. McMaster,Mark W. Cunningham,Tarek Ibrahim,Rebekah Hazlewood,Nathan Usry,Denise C. Cornelius,Lorena M. Amaral,Babbette LaMarca +8 more
TL;DR: The purpose of this study was to not only examine the effect of placental ischemia on mitochondrial-mediated oxidative stress in reduced uterine perfusion pressure (RUPP) rat model of preeclampsia but to also examine the role of mitochondrial ROS in contributing to hypertension in response to placentalIschemia.
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