Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review
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TLDR
The association between uric acid (UA) and systemic hypertension (Htn), dyslipidemia, glucose intolerance, overweight, fatty liver, renal disease and cardiovascular disease (CVD) on the other side is well recognized as discussed by the authors.About:
This article is published in Journal of Advanced Research.The article was published on 2017-09-01 and is currently open access. It has received 227 citations till now. The article focuses on the topics: Metabolic syndrome & Kidney disease.read more
Citations
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Effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors on serum uric acid level: A meta-analysis of randomized controlled trials
TL;DR: The effect of SGLT2 inhibitors on SUA reduction suggests that this class of drugs might be beneficial for diabetic patients with hyperuricaemia.
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One-pot synthesis of Au-Cu2O/rGO nanocomposite based electrochemical sensor for selective and simultaneous detection of dopamine and uric acid
TL;DR: In this article, an electrochemical sensor based on an Au-Cu2O/rGO nanocomposite for selective and simultaneous detection of dopamine and uric acid was developed.
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The role of xanthine oxidoreductase and uric acid in metabolic syndrome.
TL;DR: The dual-face role of both XOR and uric acid explains the contradictory results obtained with XOR inhibitors and suggests caution in their therapeutic use.
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Abnormal metabolism of gut microbiota reveals the possible molecular mechanism of nephropathy induced by hyperuricemia.
Li-Bin Pan,Pei Han,Shu-Rong Ma,Ran Peng,Can Wang,Wei-Jia Kong,Lin Cong,Jie Fu,Zheng-Wei Zhang,Hang Yu,Yan Wang,Jian-Dong Jiang +11 more
TL;DR: The results implied that the intestinal flora play a vital role in the pathogenesis of hyperuricemia nephropathy, and modulation of gut microbiota or targeting at metabolic enzymes, i.e., urease, could assist the treatment and prevention of this disease.
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Morphology–Dependent Electrochemical Sensing Properties of Iron Oxide–Graphene Oxide Nanohybrids for Dopamine and Uric Acid
TL;DR: The proposed d-Fe2O3/GO/GCE realized the simultaneous detection of DA and UA in human serum and urine samples with satisfactory recoveries and showed good selectivity and reproducibility.
References
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Harmonizing the Metabolic Syndrome A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
K. G. M. M. Alberti,Robert H. Eckel,Scott M. Grundy,Paul Zimmet,James I. Cleeman,Karen A. Donato,Jean Charles Fruchart,W. Philip T. James,Catherine M. Loria,Sidney C. Smith +9 more
TL;DR: It was agreed that there should not be an obligatory component, but that waist measurement would continue to be a useful preliminary screening tool, and a single set of cut points would be used for all components except waist circumference, for which further work is required.
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Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
Giulio Marchesini,Elisabetta Bugianesi,Gabriele Forlani,Fernanda Cerrelli,Marco Lenzi,R. Manini,S. Natale,Ester Vanni,Nicola Villanova,Nazario Melchionda,Mario Rizzetto +10 more
TL;DR: The presence of multiple metabolic disorders is associated with a potentially progressive, severe liver disease and the increasing prevalence of obesity, coupled with diabetes, dyslipidemia, hypertension, and ultimately the metabolic syndrome puts a very large population at risk of forthcoming liver failure in the next decades.
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Molecular identification of a renal urate anion exchanger that regulates blood urate levels.
Atsushi Enomoto,Hiroaki Kimura,Hiroaki Kimura,Arthit Chairoungdua,Yasuhiro Shigeta,Yasuhiro Shigeta,Promsuk Jutabha,Seok Ho Cha,Makoto Hosoyamada,Michio Takeda,Takashi Sekine,Takashi Igarashi,Hirotaka Matsuo,Hirotaka Matsuo,Yuichi Kikuchi,Takashi Oda,Kimiyoshi Ichida,Tatsuo Hosoya,Kaoru Shimokata,Toshimitsu Niwa,Yoshikatsu Kanai,Hitoshi Endou +21 more
TL;DR: This work identifies the long-hypothesized urate transporter in the human kidney (URAT1, encoded by SLC22A12), a urate–anion exchanger regulating blood urate levels and targeted by uricosuric and antiuricOSuric agents (which affect excretion of uric acid).
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Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study.
TL;DR: The relation of baseline serum uric acid level to incident coronary heart disease events is described and a growing body of laboratory and clinical evidence suggests that uric Acid plays a role in platelet adhesiveness, formation of free radicals, and oxidative stress.
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Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism
Marilda Mazzali,Jeremy Hughes,Yoon Goo Kim,J. Ashley Jefferson,Duk Hee Kang,Katherine L. Gordon,Hui Y. Lan,Salah D. Kivlighn,Richard J. Johnson +8 more
TL;DR: Mild hyperuricemia causes hypertension and renal injury in the rat via a crystal-independent mechanism, with stimulation of the renin-angiotensin system and inhibition of neuronal NO synthase.