Journal ArticleDOI
Pregnancies following ovum donation in gonadal dysgenesis
Dominique Cornet,Sylvia Alvarez,J.M. Antoine,C. Tibi,J. Mandelbaum,M. Plachot,Jacques Salat-Baroux +6 more
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TLDR
Only the number of embryos replaced and the substitution protocol seemed to influence the implantation rate and the other parameters, and in particular the type of gonadal dysgenesis, seemed to have no effect on the results.Abstract:
Between February 1987 and February 1989, 13 women with primary ovarian failure due to gonadal dysgenesis were treated with embryo transfer following ovum donation in 22 cycles. Eight pregnancies were obtained (36.7% per transfer); four births of normal children, two spontaneous abortions and two other pregnancies currently ongoing (between 5 and 8 months). An association of percutaneous oestradiol, oestradiol valenate and intravaginal progesterone was used as hormone substitution and embryo transfer was only performed following assessment of the endometrium during a previous cycle. Apart from the day of embryo transfer, which was the same for all patients (the 2nd day after initiation of progesterone) various prognostic factors were analysed. These were the type of gonadal dysgenesis (45 XO, 46 XX or 46 XY), the number of embryos replaced, whether they had been frozen, whether the egg donor was anonymous and finally the influence of the hormone substitution protocol. Only the number of embryos replaced and the substitution protocol seemed to influence the implantation rate. The other parameters, and in particular the type of gonadal dysgenesis, seemed to have no effect on the results. The pregnancy rate per transfer was 30% for 45 XO (10 transfers), 25% for 46 XX (eight transfers) and 75% for 46 XY (four transfers).read more
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Journal ArticleDOI
The influence of donated gametes on the incidence of hypertensive disorders of pregnancy
O. Salha,Vinay Sharma,T. Dada,D. Nugent,Anthony J. Rutherford,A.J. Tomlinson,S. Philips,Victoria Allgar,James J. Walker +8 more
TL;DR: The increased incidence of Gestational hypertension in pregnancies resulting from donated gametes gives evidence for a maternal genetic component, with an equally strong fetal influence, in the complicated aetiology of gestational hypertension, and pre-eclampsia in particular.
Journal ArticleDOI
Cytogenetic, cellular, and developmental consequences of cryopreservation of immature and mature mouse and human oocytes
TL;DR: The findings demonstrate that while profound cytoplasmic, nuclear, and nucleolar alterations occur in the immature oocyte during cryopreservation, an apparently normal nucleus and cy toplasm is re‐established progressively after thawing and culture.
Journal ArticleDOI
Turner’s syndrome and fertility: current status and possible putative prospects
TL;DR: Most women with Turner's syndrome have ovarian dysgenesis; therefore, they are usually infertile, and in very rare cases have spontaneous menses followed by early menopause, but methods of replantation and in-vitro maturation still need to be developed.
Journal ArticleDOI
The absorption of oral micronized progesterone: the effect of food, dose proportionality, and comparison with intramuscular progesterone*†
James A. Simon,James A. Simon,James A. Simon,Denise E. Robinson,Denise E. Robinson,Denise E. Robinson,Mason C. Andrews,Mason C. Andrews,Mason C. Andrews,James R. Hildebrand,James R. Hildebrand,James R. Hildebrand,Mario L. Rocci,Mario L. Rocci,Mario L. Rocci,Richard E. Blake,Richard E. Blake,Richard E. Blake,Gary D. Hodgen,Gary D. Hodgen,Gary D. Hodgen +20 more
TL;DR: In this article, the effects of food ingestion and administered dose on the absorption of oral micronized Utrogestan (Utrovestan; Besins-Iscovesco, Paris, France) and compared the bioavailability of intramuscular versus oral routes of administration were examined.
Journal ArticleDOI
Obstetric outcome in 232 ovum donation pregnancies
TL;DR: The objective is to study the obstetric outcome of ovum donation pregnancies and to establish a baseline level of confidence that ovarian donation pregnancies are safe and effective for women with high-risk pregnancies.