Preliminary study of protective effects of flavonoids against radiation-induced lung injury in mice.
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TLDR
From the results of the present study, flavonoids could be excellent candidates as protective agents against radiation-induced lung injury.Abstract:
Background Radiation therapy plays an important role in lung carcinoma treatment. However, the incidence of symptomatic radiation-induced lung injury is high. This study aimed to evaluate radioprotective effects of flavonoids extracted from Astragalus complanatus and mechanisms of action against radiation damage. Methods Alteration in antioxidant status and levles of several cytokines were investigated in BABL/C mice treated with 4 mg/kg b.wt. flavonoids after exposure to 10Gy thoracic radiation. Results Serum levels of SOD in the flavonoids+radiation group were significantly higher compared to the radiation control group, while TGF-β1 and IL-6 were lower. Mice in the radiation control group displayed more severe lung damage compared with the flavonoids+radiation group. The expression of TGF-β1 and TNF-α in the radiation control group was markedly increased in alveolar epithelial cells and macrophages of the alveolar septum. Conclusions From the results of the present study, flavonoids could be excellent candidates as protective agents against radiation-induced lung injury.read more
Citations
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Flavonoids from the Genus Astragalus: Phytochemistry and Biological Activity.
TL;DR: Details on structure as well as information about the pharmacological properties of flavonoids, isolated from Astragalus species have been discussed and the results from phytochemical investigations of the genus are included.
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TL;DR: The predictive power and biological relevance of the DILD network is demonstrated by applying it to identify drugs with relevant pharmacological mechanisms for treating lung injury and the utility of ILP modeling is illustrated with a case study of drug induced lung injury.
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Plant Extracts and Plant-Derived Compounds: Promising Players in Countermeasure Strategy Against Radiological Exposure: A Review
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Preventive and therapeutic effects of quercetin on experimental radiation induced lung injury in mice
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TL;DR: Some of the recent advances in flavonoid research are reviewed and the role of anthocyanins and flavones in providing stable blue flower colours in the angiosperms is outlined.
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TL;DR: This review summarizes available data on these beneficial effects of flavonoids and suggests that the compounds may possess significant antihepatotoxic, antiallergic, anti-inflammatory, antiosteoporotic and even antitumor activities.
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Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands
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