Journal ArticleDOI
Preparation of metabolizable radioactive human serum albumin microspheres for studies of the circulation.
TLDR
Radioactive μspheres have been prepared from human serum albumin (HSA) in sizes between 12 and 44 &μ; and they have advantages over other particles that are now being used for studies of the circulation.About:
This article is published in The International Journal of Applied Radiation and Isotopes.The article was published on 1970-03-01. It has received 119 citations till now. The article focuses on the topics: Serum albumin & Blood serum.read more
Citations
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Journal ArticleDOI
Blood flow measurements with radionuclide-labeled particles.
TL;DR: The microsphere technique is relatively simple and extremely accurate when appropriately and correctly applied, and it can be used to quantify arteriovenous anastomoses as well as the measurement of organ blood flows and distribution of blood flow within those organs.
Journal ArticleDOI
Nanoparticle Technology for Drug Delivery Across the Blood-Brain Barrier
TL;DR: NP technology appears to have significant promise in delivering therapeutic molecules across the blood-brain barrier and primary methods of NP preparation and characterization are described.
Journal ArticleDOI
Biodegradable poly(lactic acid) and poly(lactide-co-glycolide) microcapsules: problems associated with preparative techniques and release properties.
R. Jalil,J. R. Nixon +1 more
TL;DR: In vivo and in vitro drug release from these microcapsules is reviewed and problems associated with the different microencapsulation techniques using PLA or PLCG are reviewed.
BookDOI
Fundamentals and applications of controlled release drug delivery
TL;DR: The Need for Drugs and Drug Delivery Systems, and the Shaping of Controlled Release Drug Product Development by Emerging Trends in the Commercial, Regulatory and Political Macro-Environment.
Journal ArticleDOI
Magnetic Microspheres: Synthesis of a Novel Parenteral Drug Carrier
TL;DR: The synthesis and characterization of a novel parenteral drug carrier capable of area specific localization by magnetic means and release doxorubicin was chemically identical to the starting material.
References
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Journal ArticleDOI
The Circulation of the Fetus in Utero METHODS FOR STUDYING DISTRIBUTION OF BLOOD FLOW, CARDIAC OUTPUT AND ORGAN BLOOD FLOW
TL;DR: Experimental evidence is provided that (1) there is no significant recirculation of microspheres, (2) the distribution of spheres is proportional to flow, and (3) circulatory physiology is not altered by injection of spheres.
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Use of radioactive microspheres to assess distribution of cardiac output in rabbits
JM Neutze,F Wyler,AM Rudolph +2 more
Journal ArticleDOI
Diagnosis of Massive Pulmonary Embolism in Man by Radioisotope Scanning
TL;DR: The diagnosis of massive pulmonary embolism is frequently difficult and always uncertain, primarily because the symptoms and signs may mimic those of some other diseases, such as myocardial infarction or pneumonia.
Journal ArticleDOI
Measure- ment of distribution of cardiac output.
Journal ArticleDOI
Radioactive Albumin Microspheres for Studies of the Pulmonary Circulation
TL;DR: The most common radiopharmaceutical for determining the distribution of pulmonary arterial blood flow is 131 -labeled macroaggregates of human serum albumin, but more recently both 113mIn-labeled floes of iron hydroxide and 99mTc- labeled MAA have also been used.