Prevalence and characteristics of neuropathic pain in leprosy patients treated years ago.
José Ramos,Beatriz Alonso-Castañeda,Dejene Eshetu,Deriba Lemma,Francisco Reyes,Isabel Belinchón,Miguel Górgolas +6 more
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TLDR
Neuropathic pain is common in patients treated for leprosy and in more than half of them, it causes disruption in their daily life and sleep, limiting their quality of life even more.Abstract:
The aim of this study was to determine the prevalence of neuropathic pain, now recognized as another late complication of leprosy, and its characteristics among leprosy patients. A cross-sectional study was carried out of people treated for leprosy up to at least 5 years ago in a rural area of Ethiopia. Seventy-four patients were interviewed using the Neuropathic Pain Symptom Inventory (NPSI) questionnaire. In total, 78.9% of the patients were female with a mean age of 42.9. The mean time from initial diagnosis to the time of the study was 28.0 years, and 73.0% of patients were diagnosed over 20 years ago. Fifty-two (70.3%) reported having symptoms suggestive of neuropathic pain and the majority described the pain as burning (88.5%), electric (80.8%), stabbing (76.9%), cutting (76.9%), tingling (65.4%), squeezing (57.7%), and/or pressure (53.8%). The pain caused a severe or moderate impact on daily life in 75% and 57.7% of cases, respectively, and 92.3% suffered from disrupted sleep. Eighty percent of patients with pain (42/52) took some medication for pain relief. Neuropathic pain is common in patients treated for leprosy and in more than half of them, it causes disruption in their daily life and sleep, limiting their quality of life even more.read more
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Pain and quality of life in leprosy patients in an endemic area of Northeast Brazil: a cross-sectional study
Victor Santana Santos,Jamilly C. V. Santana,Fabrícia D. N. Castro,Laudice Santos Oliveira,Julianne C. V. Santana,Vera Lúcia Corrêa Feitosa,Ricardo Queiroz Gurgel,Luis E. Cuevas +7 more
TL;DR: Pain is highly prevalent among leprosy patients and is associated with low quality of life, and Leprosy management should include a systematic assessment of the type of pain a patient experiences in order to provide adequate treatment.
Journal ArticleDOI
Epidemiology of neuropathic pain
TL;DR: Data on the incidence and/or prevalence of chronic pain with neuropathic characteristics are very different and although this type of pain is being broadly studied in recent years, epidemiological studies are relatively scarce and the methodology used varies a lot.
Journal ArticleDOI
Diagnosis and impact of neuropathic pain in leprosy patients in Nepal after completion of multidrug therapy.
Han-Siong Toh,Jeni Maharjan,Ruby Thapa,Kapil D. Neupane,Mahesh Shah,Suwash Baral,Deanna A. Hagge,Indra B. Napit,Diana N. J. Lockwood +8 more
TL;DR: Investigating NP prevalence and impact in the years after patients are declared “released from treatment” (RFT) following multidrug therapy (MDT) completion finds that 35% of RFT patients had ongoing NP.
Journal ArticleDOI
Acute and chronic pain associated with leprosy.
Siddarth Thakur,Robert H. Dworkin,Omer M.O. Haroun,Diana N. J. Lockwood,Andrew S.C. Rice,Andrew S.C. Rice +5 more
TL;DR: Although the M leprae infection is curable, patients remain at long-term risk of complications (including neuropathic pain) from existing nerve damage and also further nerve damage from reactions, and all patients should receive multidrug treatment to treat the infection and reduce the development of drug-resistant M lePrae.
Journal ArticleDOI
Cytokine Levels in Neural Pain in Leprosy.
Angst Dbm,Roberta Olmo Pinheiro,Vieira Jsds,Cobas Ra,Hacker Mav,Pitta Ijr,Pitta Ijr,Louise Giesel,Euzenir Nunes Sarno,Jardim Mr,Jardim Mr,Jardim Mr +11 more
TL;DR: Analysis of cytokine levels have demonstrated that IL-1β is an independent variable related to neuropathic and nociceptive pain in patients with leprosy, and could be an important biomarker for patient follow-up.
References
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Journal ArticleDOI
Development and validation of the Neuropathic Pain Symptom Inventory
Didier Bouhassira,Nadine Attal,Jacques Fermanian,Haiel Alchaar,Michèle Gautron,Etienne Masquelier,Sylvie Rostaing,Michel Lanteri-Minet,Elisabeth Collin,Jacques Grisart,François Boureau +10 more
TL;DR: The psychometric properties of the NPSI suggest that it might be used to characterize subgroups of neuropathic pain patients and verify whether they respond differentially to various pharmacological agents or other therapeutic interventions.
Journal ArticleDOI
Leprosy now: epidemiology, progress, challenges, and research gaps
TL;DR: In this paper, the authors review data and make recommendations for research on diagnosis, treatment, and prevention, such as further use of molecular analysis of the Mycobacterium leprae genome, implementation of BCG vaccination, and administration of chemoprophylaxis to household contacts.
Journal ArticleDOI
Repeatability of Pain Drawings in a Low Back Pain Population
TL;DR: Finding acceptable repeatability for most scoring methods for pain drawing completed on occasions separated by a relatively long period of time, support that the pain drawing is a stable instrument for use in chronic back pain patients.
Journal ArticleDOI
Comparison of psychological and physical function in neuropathic pain and nociceptive pain: Implications for cognitive behavioral pain management programs
H. Clare Daniel,H. Clare Daniel,Jane Narewska,Michael Serpell,Barbara Hoggart,Robert W. Johnson,Andrew S.C. Rice +6 more
TL;DR: The results suggest that the differences between the two groups were not on the major variables of pain, mood, cognition and physical function, and the main differences were in factors that increase pain, people's responses to pain, and their beliefs about diagnosis and the cause of pain.
Journal ArticleDOI
Nerve damage in leprosy: a continuing challenge to scientists, clinicians and service providers
TL;DR: Evidence is presented to support the argument that leprosy is best seen as a chronic neurological condition rather than a simple skin disease and treatment with steroids can be effective but about 50% of patients relapse and require a further course of steroids.
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