Journal ArticleDOI
Programmable One‐Pot Oligosaccharide Synthesis.
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This article is published in ChemInform.The article was published on 1999-06-15. It has received 146 citations till now.read more
Citations
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Journal ArticleDOI
Opportunities and challenges in synthetic oligosaccharide and glycoconjugate research
TL;DR: Synthetic oligosaccharides and glycoconjugates are increasingly used as probes for biological research and as lead compounds for drug and vaccine discovery, and the power of carbohydrate chemistry is highlighted by an ability to synthesize glycoproteins.
Journal ArticleDOI
Regioselective one-pot protection of carbohydrates
Cheng-Chung Wang,Jinq-Chyi Lee,Shun-Yuan Luo,Suvarn S. Kulkarni,Yu-Wen Huang,Chia-Chen Lee,Ken-Lien Chang,Shang-Cheng Hung +7 more
TL;DR: A combinatorial, and highly-regioselective, method that can be used to protect individual hydroxy groups of a monosaccharide in a single reaction vessel, which removes the need to carry out the time-consuming isolation and purification of intermediates.
Journal ArticleDOI
Carbohydrate microarrays - a new set of technologies at the frontiers of glycomics.
TL;DR: Results of 'proof of concept' experiments with carbohydrate-binding proteins of the immune system and several plant lectins indicate that microarrays of carbohydrates will greatly facilitate not only surveys of proteins for carbohydrates-binding activities but also elucidation of their ligands.
Journal ArticleDOI
Chemical glycosylation in the synthesis of glycoconjugate antitumour vaccines
Danica P. Galonić,David Y. Gin +1 more
TL;DR: This work has shown that the use of both state-of-the-art and emerging glycosylation technologies has led to significant advances in this field, allowing the clinical exploration of carbohydrate-based antigens in the treatment of cancer.
Journal ArticleDOI
Automated Chemical Oligosaccharide Synthesis: Novel Approach to Traditional Challenges.
TL;DR: The overarching goal of this review article is to present the advances that have been made at the interface of carbohydrate chemistry and automated technology.
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PatentDOI
Programmable one-pot oligosaccharide synthesis
TL;DR: In this article, the reactivity of a number of p-methylphenyl thioglycoside (STol) donors which are either fully protected or have one hydroxyl group exposed has been quantitatively determined by HPLC in conjunction with the development of a broadly applicable approach for a facile one-pot synthesis of oligosaccharides.