Protein composition of Lp(a) lipoprotein from human plasma
Gerd Utermann,W. Weber +1 more
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The unreduced detergent delipidized protein moiety from Lp(a) lipoprotein shows a single band of M r ∼700000 in SDS—polyacrylamide gel electrophoresis and the immunoprecipitates formed against anti‐Lp( a) and anti‐apo B by the unreducing protein show a reaction of immunological identity.About:
This article is published in FEBS Letters.The article was published on 1983-04-18 and is currently open access. It has received 240 citations till now. The article focuses on the topics: Lipoprotein & Gel electrophoresis.read more
Citations
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The mysteries of lipoprotein(a)
TL;DR: Though of high theoretical and practical interest, many aspects of the metabolism, function, evolution, and regulation of plasma concentrations of Lp(a) are presently unknown, controversial, or mysterious.
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Lp(a) glycoprotein phenotypes. Inheritance and relation to Lp(a)-lipoprotein concentrations in plasma.
TL;DR: Results from neuraminidase treatment of isolated Lp(a) glycoprotein indicate that the phenotypic differences do not reside in the sialic acid moiety of the glycop protein, and is the first indication for structural differences underlying the quantitative genetic Lp (a)-trait.
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Lipoprotein(a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis.
TL;DR: It is reported here that lipoprotein(a) interferes with endothelial cell fibrinolysis by inhibiting plasminogen binding and hence plAsmin generation, and lipop protein accumulation in atherosclerotic lesions is demonstrated.
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The association between serum Lp(a) concentrations and angiographically assessed coronary atherosclerosis. Dependence on serum LDL levels.
Victor W. Armstrong,Peter Cremer,E. Eberle,A. Manke,F. Schulze,Heinrich Wieland,Heinrich Kreuzer,Dietrich Seidel +7 more
TL;DR: The data suggest that increasing LDL concentrations markedly increase the risk of coronary artery disease due to elevated Lp(a) levels, independent of the known risk factors smoking, hypertension and diabetes.
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A potential basis for the thrombotic risks associated with lipoprotein(a).
TL;DR: Support is provided for such a mechanism being responsible for the thrombotic risks associated with elevated Lp(a) by demonstrating that Lp (a) inhibits plasminogen binding to cells.
References
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The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis
Klaus Weber,Mary Osborn +1 more
TL;DR: The results show that the polyacrylamide gel electrophoresis method can be used with great confidence to determine the molecular weights of polypeptide chains for a wide variety of proteins.
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The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum
TL;DR: The relatively low density of the lipoproteins was utilized by Lindgren, Elliott, and Gofman to separate them from the other serum proteins by ultracentrifugal flotation, and quantitation was subsequently performed by refractometric methods in the analytical ultracentRifuge.
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Lipoprotein Lp(a) and the risk for myocardial infarction
TL;DR: It is concluded that Lp(a) represents an independent addi tional risk factor for MI with a possible threshold value of approx.
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Heterogeneity of apolipoprotein B: isolation of a new species from human chylomicrons
TL;DR: Four species of apolipoprotein B are isolated with unique molecular weights and amino acid compositions and assigned numerical designations to these species in a centile system based upon their relative apparent Mr in NaDodSO4.