Journal ArticleDOI
Purines: supply by liver to tissues.
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This article is published in American Journal of Physiology.The article was published on 1970-11-01. It has received 74 citations till now.read more
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Journal ArticleDOI
Effect of renal failure on erythrocyte purine nucleotide, nucleoside and base concentrations and some related enzyme activities.
TL;DR: The mean activities of some of the enzymes involved in purine metabolism were raised in renal failure and erythrocyte phosphoribosylpyrophosphate levels were unchanged, and high-pressure liquid chromatography concentrations in erythrocytes and plasma were raised.
Journal ArticleDOI
32P labelling of the nucleotides in α-position in the rabbit heart
TL;DR: The time course labelling of inorganic phosphate, creatine phosphate, terminal phosphate group of ATP (γ-P (ATP), and of the α-phosphate groups of nucleotides was followed in the rabbit heart both “ in situ ” and in perfusion, and the methodology and the results are discussed in relation to synthesis of free nucleotide.
Book ChapterDOI
Immunological Aspects of Purine Metabolism
J. Edwin Seegmiller,J. Edwin Seegmiller,J. Edwin Seegmiller,T. Watanabe,T. Watanabe,T. Watanabe,Max H. Shreier,Max H. Shreier,Max H. Shreier,Thomas A. Waldmann,Thomas A. Waldmann,Thomas A. Waldmann +11 more
TL;DR: Evidence is presented of the need for a rapid rate of purine synthesis de novo for the proliferative events in this process and of the correction of the immune response by addition of ADA both in vitro and in vivo.
Journal ArticleDOI
Incorporation of the purine moieties of guanosine and inosine analogs into nucleotide pools of human erythrocytes.
Chong M. Kong,Robert E. Parks +1 more
TL;DR: It is proposed that the analog nucleosides are first split by purine nucleoside phosphorylase (PNPasc), liberating the corresponding free base, which then reacts with 5-phosphoribosyl-1-pyrophosphate (PRPP) and the salvage enzyme, hypoxanthine-guanine phosphorIBosyltransferase (HGPRTase) to form analog monophosphate nucleotides.
Journal ArticleDOI
Primary pulmonary hypertension.
TL;DR: Adenosine: electrophysiologic effects and therapeutic use for terminating paroxysmal supraventricular tachycardia and Effect of adenosine on sinoatrialand ventricular automaticity of the guinea pig.