Quantitative Analysis of Fecal Flora in Goat Kids with and without Floppy Kid Syndrome
Ulrich Bleul,N Fassbind,Giovanni Ghielmetti,D Zoller,Annette Liesegang,Michael Hässig,Max M. Wittenbrink,S Prohaska +7 more
TLDR
The groups of bacteria present in greater numbers in the feces of goat kids with FKS include several D-lactate-producing species, which makes dysbacteriosis a likely cause of the increased plasma D- lactate concentration in FKS.Abstract:
Background
Floppy kid syndrome (FKS) affects goat kids in the first month of life and is associated with high morbidity and mortality rates. The condition is characterized by neurological signs that can be ascribed to increased plasma d-lactate concentrations. The source of d-lactate has not been identified conclusively, but d-lactate-producing bacteria in the large intestine are thought to be involved.
Objectives
To determine the number of colony-forming unit (CFUs) of certain groups of bacteria in the feces of kids with and without FKS.
Animals
Nineteen goat kids with clinical signs of FKS, acidemia (pH ≤ 7.2), and plasma d-lactate concentration >7 mM and 15 healthy goat kids without acidemia (pH >7.2) and d-lactate concentration <1 mM.
Methods
In this case-control study, the goat kids were examined clinically and blood was collected to measure d-lactate concentration, blood gases, and acid–base parameters. Fecal samples were collected and the total aerobic bacterial count and CFU counts of coliforms, enterococci, staphylococci, streptococci, lactobacilli, and clostridia were determined using the surface plating method.
Results
Goat kids with FKS had a mean plasma d-lactate concentration of 10.9 ± 3.7 mM compared with 0.3 ± 0.9 mM in healthy kids, and significantly greater CFU counts for enterococci, streptococci, staphylococci, and lactobacilli than healthy kids.
Conclusions and Clinical Importance
The groups of bacteria present in greater numbers in the feces of goat kids with FKS include several d-lactate-producing species, which makes dysbacteriosis a likely cause of the increased plasma d-lactate concentration in FKS.read more
Citations
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Journal ArticleDOI
d-Lactic Acidosis in Neonatal Ruminants
Ingrid Lorenz,Arcangelo Gentile +1 more
TL;DR: This article summarizes the available information on D-lactic metabolic acidosis in neonatal ruminants and describes the development of stereospecific assays for the measurement of L-lactate.
Journal ArticleDOI
Evaluation of the specificity of intradermal tuberculin and serological tests for diagnosis of tuberculosis in alpaca (Vicugna pacos) and llama (Lama glama) herds under field conditions in Peru.
Javier Bezos,Beatriz Romero,A. Delgado,Julio Alvarez,Carmen Casal,Ángel Venteo,I. Gonzalez,Lucas Domínguez,L. de Juan +8 more
TL;DR: The aim of this study was to evaluate the Sp of the intradermal tuberculin test and a novel serological assay for diagnosis of TB in two different TB-free herds of alpacas and llamas located in different regions in Peru.
References
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Book
Veterinary Microbiology and Microbial Disease
TL;DR: Machine generated contents note: Section I: Introductory Bacteriology, Pathogenic Bacteria, Mycology, Viruses and Prions, Microbial Agents and Disease Production.
Journal ArticleDOI
d-Lactate in Human and Ruminant Metabolism
TL;DR: Advances in the understanding of D-lactate metabolism, D- lactic acidosis in ruminants and humans, and subclinical elevation of d- lactate are described.
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D-lactic acidosis. A review of clinical presentation, biochemical features, and pathophysiologic mechanisms.
TL;DR: Analysis of published data shows a substantial rate of metabolism of d-lactate by normal humans, and estimates suggest that impaired metabolism of lactate is almost a prerequisite for the development of the syndrome.
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George M. Garrity,James R. Cole,Timothy Lilburn,Scott H. Harrison,Jean Euzeby,Brian J. Tindall +5 more
TL;DR: The focus of that meeting was to discuss how a large-scale project could be organized that would result in sequencing the genomes of all the type strains of the species recognised by a combination of the Rules of the Bacteriological Code and current taxonomic interpretation.