Quantitative and sensitive in vitro assay for osteoinductive activity of demineralized bone matrix.
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TLDR
Results from DBM batches, originating from five established Bone Banks, showed good consistency between in vitro and in vivo assays, however, DBM activity varied widely from bank to bank as well as from batch to batch within the same bank.About:
This article is published in Journal of Orthopaedic Research.The article was published on 2003-07-01 and is currently open access. It has received 120 citations till now. The article focuses on the topics: Demineralized bone matrix & dBm.read more
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Patent
Delivery system attachment
Guobao Wei,Keyvan Behnam,Nanette Forsyth,John Winterbottom,James Beisser,Todd M. Boyce,Mohamed Attawia,Cristy Richards,Lawrence A. Shimp +8 more
TL;DR: In this paper, a covering for delivering a substance or material to a surgical site is provided, with substance provided therein, may be referred to as a delivery system, and the covering may participate in, control, or otherwise adjust, the release of the substance.
Journal ArticleDOI
Osteoinductive biomaterials: current knowledge of properties, experimental models and biological mechanisms.
TL;DR: The properties of osteoinductive biomaterials are reviewed, in the light of the model and the conditions under which they were tested, to give an insight into the biological processes governing osteo Induction by biommaterials and the view on the future perspectives in this research field.
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Segmented delivery system
TL;DR: In this paper, a covering for delivering a substance or material to a surgical site is provided, with substance provided therein, may be referred to as a delivery system, and the covering may participate in, control, or otherwise adjust the release of the substance.
Journal ArticleDOI
Ectopic bone formation by microporous calcium phosphate ceramic particles in sheep muscles.
Damien Le Nihouannen,Guy Daculsi,Afchine Saffarzadeh,Olivier Gauthier,Séverine Delplace,Paul Pilet,Pierre Layrolle +6 more
TL;DR: The overall results therefore confirmed the presence of mature bone after intramuscular implantation of MBCP granules, and the different hypotheses explaining ectopic bone formation induced by MBCp granules are discussed.
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Bone Matrix Compositions and Methods
TL;DR: An osteoinductive composition, corresponding osteoimplants, and methods for making the osteo-inductive composites are disclosed in this article, where the authors present an osteoimplant, which can induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization and bone marrow differentiation.
References
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Bone: Formation by Autoinduction
TL;DR: Differentiation of the osteoprogenitor cell is elicited by local alterations in cell metabolic cycles that are as yet uncharacterized and may transfer collagenolytic activity to the substrate to cause dissolution of the matrix.
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Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage.
Takenobu Katagiri,Akira Yamaguchi,Motohiro Komaki,Etsuko Abe,Naoyuki Takahashi,Tohru Ikeda,Rosen,J M Wozney,A Fujisawa-Sehara,Tatsuo Suda +9 more
TL;DR: Results indicate that BMP-2 specifically converts the differentiation pathway of C2C12 myoblasts into that of osteoblast lineage cells, but that the conversion is not heritable.
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Biochemical Sequences in the Transformation of Normal Fibroblasts in Adolescent Rats
A. H. Reddi,Charles Huggins +1 more
TL;DR: Coarse powders of acid-insoluble matrix of diaphysis and calvarial parietal bone rapidly and consistently transformed fibroblasts into masses of cartilage and bone containing hemopoietic marrow.
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Bone morphogenetic proteins: from basic science to clinical applications.
TL;DR: The role of bone matrix as a repository of BMPs is described and some of this new information may be of clinical relevance because it suggests potential therapeutic approaches to enhance or suppress new bone formation.
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Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation.
Takanori Ebisawa,K. Tada,I. Kitajima,K. Tojo,T.K. Sampath,Masahiro Kawabata,Kohei Miyazono,Takeshi Imamura +7 more
TL;DR: The findings indicate that in the process of differentiation to osteoblasts, BMP-6 binds to ALK-2 as well as other type I receptors, and transduces signals mainly through Smad5 and possibly throughSmad1.