Quantitative Monte Carlo–Based 90Y SPECT Reconstruction
Mattijs Elschot,Marnix G.E.H. Lam,Maurice A.A.J. van den Bosch,Max A. Viergever,Hugo W. A. M. de Jong +4 more
TLDR
The quantitative accuracy of 90Y bremsstrahlung SPECT is substantially improved by Monte Carlo–based modeling of the image-degrading factors and may be used as an alternative to 90Y PET.Abstract:
The evaluation of radiation absorbed doses in tumorous and healthy tissues is of increasing interest for 90Y microsphere radioembolization of liver malignancies. The objectives of this work were to introduce and validate a new reconstruction method for quantitative 90Y bremsstrahlung SPECT to improve posttreatment dosimetry. Methods: A fast Monte Carlo simulator was adapted for 90Y and incorporated into a statistical reconstruction algorithm (SPECTMC). Photon scatter and attenuation for all photons sampled from the full 90Y energy spectrum were modeled during reconstruction by Monte Carlo simulations. The energy- and distance-dependent collimator–detector response was modeled with precalculated convolution kernels. The National Electrical Manufacturers Association 2007/International Electrotechnical Commission 2008 image quality phantom was used to quantitatively evaluate the performance of SPECT-MC in comparison with those of state-of-the-art clinical SPECT reconstruction and PET. The liver radiation absorbed doses estimated by SPECT, PET, and SPECT-MC were evaluated in 5 patients consecutively treated with radioembolization. Results: In comparison with state-of-the-art clinical 90 Y SPECT reconstruction, SPECT-MC substantially improved image contrast (e.g., from 25% to 88% for the 37-mm sphere) and decreased the mean residual count error in the lung insert (from 73% to 15%) at the cost of higher image noise. Image noise and the mean count error were lower for SPECT-MC than for PET. Image contrast was higher in the larger spheres (diameter of $28 mm) but lower in the smaller spheres (#22 mm) for SPECT-MC than for PET. In the clinical study, mean absorbed dose estimates in liver regions with high absorbed doses were consistently higher for SPECT-MC than for SPECT (P 5 0.0625) and consistently higher for SPECT-MC than for PET (P 5 0.0625). Conclusion: The quantitative accuracy of 90Y bremsstrahlung SPECT is substantially improved by Monte Carlo–based modeling of the image-degrading factors. Consequently, 90Y bremsstrahlung SPECT may be used as an alternative to 90Y PET.read more
Citations
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Journal ArticleDOI
Determination of Radiation Absorbed Dose to Primary Liver Tumors and Normal Liver Tissue Using Post-Radioembolization 90Y PET
Shyam Srinivas,Navin Natarajan,Joshua Kuroiwa,Sean Gallagher,Elie Nasr,Shetal N. Shah,Frank P. DiFilippo,Nancy A. Obuchowski,Bana Bazerbashi,Naichang Yu,Gordon McLennan +10 more
TL;DR: This retrospective study of 56 patients with HCC showed a possible dose–response trend for the tumors and measured and correlated the dose of radiation delivered to liver tumors and normal liver tissue using glass microspheres to the frequency of complications with modified response evaluation criteria in solid tumors (mRECIST).
Journal ArticleDOI
Radioembolization and the Dynamic Role of 90Y PET/CT
Alexander S. Pasciak,Alexander S. Pasciak,Austin C. Bourgeois,J. Mark McKinney,Ted Chang,Ted Chang,Dustin Osborne,Shelley Acuff,Yong Bradley +8 more
TL;DR: The broad utilization of 90 Y PET has the potential to provide a wealth of dose–response information, which may lead to development of improved radioembolization treatment-planning models in the future.
Journal ArticleDOI
Theranostic Imaging of Yttrium-90.
TL;DR: Although challenges remain for 90Y imaging, continued clinical demand for predictive imaging response assessment and target/nontarget dosimetry will drive research and technical innovation to provide greater clinical utility of 90Y as a theranostic agent.
Journal ArticleDOI
The physics of radioembolization
Remco Bastiaannet,S. Cheenu Kappadath,Britt Kunnen,Arthur J. A. T. Braat,Marnix G.E.H. Lam,Hugo W. A. M. de Jong +5 more
TL;DR: This review concludes with a discussion on areas where further research is necessary in order to arrive at a personalized treatment method that provides optimal tumor control and is clinically feasible.
Journal ArticleDOI
Holmium-166 Microsphere Radioembolization of Hepatic Malignancies.
TL;DR: An overview of relevant dosing aspects, technical aspects of performing holmium radioembolization, as well as a summary of completed and ongoing clinical studies and the upcoming developments regarding these microspheres are provided.
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