MIRD Pamphlet No. 24: Guidelines for Quantitative 131I SPECT in Dosimetry Applications
Yuni K. Dewaraja,Michael Ljungberg,A J Green,Pat Zanzonico,Eric C. Frey,Wesley E. Bolch,A. Bertrand Brill,Mark Dunphy,Darrell R. Fisher,Roger W. Howell,Ruby F. Meredith,George Sgouros,Barry W. Wessels +12 more
TLDR
The purpose of this document is to provide guidance on the development of protocols for quantitative 131I SPECT in radionuclide therapy applications that require regional (normal organs, lesions) and 3-dimensional dosimetry.Abstract:
The reliability of radiation dose estimates in internal radionuclide therapy is directly related to the accuracy of activity estimates obtained at each imaging time point. The recently published MIRD pamphlet no. 23 provided a general overview of quantitative SPECT imaging for dosimetry. The present document is the first in a series of isotope-specific guidelines that will follow MIRD 23 and focuses on one of the most commonly used therapeutic radionuclides, 131I. The purpose of this document is to provide guidance on the development of protocols for quantitative 131I SPECT in radionuclide therapy applications that require regional (normal organs, lesions) and 3-dimensional dosimetry.read more
Citations
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The joint IAEA, EANM, and SNMMI practical guidance on peptide receptor radionuclide therapy (PRRNT) in neuroendocrine tumours
John Zaknun,Lisa Bodei,Jan Mueller-Brand,Marianne Pavel,Richard P. Baum,Dieter Hörsch,M. O'Dorisio,T. M. O’Dorisiol,James R. Howe,Marta Cremonesi,Dik J. Kwekkeboom +10 more
TL;DR: This guidance covers the rationale, indications and contraindications for PRRNT, assessment of treatment response and patient follow-up, and is aimed at guiding nuclear medicine specialists in selecting likely candidates to receive PRR NT and to deliver the treatment in a safe and effective manner.
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Initial Evaluation of [18F]DCFPyL for Prostate-Specific Membrane Antigen (PSMA)-Targeted PET Imaging of Prostate Cancer
Zsolt Szabo,Esther Mena,Steven P. Rowe,Donika Plyku,Rosa Nidal,Mario A. Eisenberger,Emmanuel S. Antonarakis,Hong Fan,Robert F. Dannals,Ying Chen,Ronnie C. Mease,Melin Vranesic,Akrita Bhatnagar,George Sgouros,Steve Y. Cho,Steve Y. Cho,Martin G. Pomper +16 more
TL;DR: Initial safety, biodistribution, and radiation dosimetry results with [18F]DCFPyL, a second-generation fluorine-18-labeled small-molecule PSMA inhibitor, in patients with prostate cancer are presented and its accumulation is high in presumed primary and metastatic foci.
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An Evidence-Based Review of Quantitative SPECT Imaging and Potential Clinical Applications
TL;DR: SPECT continues to suffer from poorer photon detection efficiency and spatial resolution than PET; however, it has the benefit in some situations of longer radionuclide half-lives, which may better suit the biologic process under examination, as well as the ability to perform multitracer studies using pulse height spectroscopy to separate different radiolabels.
Journal ArticleDOI
MIRD Pamphlet No. 23: Quantitative SPECT for Patient-Specific 3-Dimensional Dosimetry in Internal Radionuclide Therapy
Yuni K. Dewaraja,Eric C. Frey,George Sgouros,A. Bertrand Brill,Peter L. Roberson,Pat Zanzonico,Michael Ljungberg +6 more
TL;DR: An overview of 3-dimensional SPECT methods and requirements for internal dosimetry at both regional and voxel levels is presented, and Combined SPECT/CT image-based methods are emphasized, because the CT-derived anatomic information allows one to address multiple technical factors that affect SPECT quantification while facilitating the patient-specific voxels-level dosimetric calculation itself.
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Radiopharmaceutical therapy in cancer: clinical advances and challenges.
TL;DR: An overview of the fundamental properties of radiopharmaceutical therapy is provided, agents in use and in clinical development are discussed and the associated translational challenges are highlighted.
References
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A Monte Carlo program for the simulation of scintillation camera characteristics
TL;DR: The usefulness of the Monte Carlo code for the accurately simulation of important parameters in scintillation camera systems, stationary as well as SPECT (single-photon emission computed tomography) systems, has been demonstrated.
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MIRD Pamphlet No. 23: Quantitative SPECT for Patient-Specific 3-Dimensional Dosimetry in Internal Radionuclide Therapy
Yuni K. Dewaraja,Eric C. Frey,George Sgouros,A. Bertrand Brill,Peter L. Roberson,Pat Zanzonico,Michael Ljungberg +6 more
TL;DR: An overview of 3-dimensional SPECT methods and requirements for internal dosimetry at both regional and voxel levels is presented, and Combined SPECT/CT image-based methods are emphasized, because the CT-derived anatomic information allows one to address multiple technical factors that affect SPECT quantification while facilitating the patient-specific voxels-level dosimetric calculation itself.
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Quantitative Accuracy of Clinical 99mTc SPECT/CT Using Ordered-Subset Expectation Maximization with 3-Dimensional Resolution Recovery, Attenuation, and Scatter Correction
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Accuracy of quantitative reconstructions in SPECT/CT imaging
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