Quantitative radionuclide assessment of regional ventricular function after thrombolytic therapy for acute myocardial infarction: results of phase I Thrombolysis in Myocardial Infarction (TIMI) trial.
Frans J. Th. Wackers,Michael L. Terrin,David S. Kayden,Genell L. Knatterud,Sandra A. Forman,Eugene Braunwald,Barry L. Zaret +6 more
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TLDR
This study suggests a direct relation between improvement of regional left ventricular function and the greater infarct-related artery patency rate achieved by rt-PA compared with streptokinase.About:
This article is published in Journal of the American College of Cardiology.The article was published on 1989-04-01 and is currently open access. It has received 42 citations till now. The article focuses on the topics: Streptokinase & Ejection fraction.read more
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Influence of coronary collateral vessels on myocardial infarct size in humans. Results of phase I thrombolysis in myocardial infarction (TIMI) trial. The TIMI Investigators.
TL;DR: The results demonstrate that, in patients in whom thrombolytic therapy fails to induce reperfusion, the presence of coronary collateral vessels at the onset of myocardial infarction is associated with limitation of infarct size as assessed enzymatically and with improved ventricular function on discharge as assessed by LVEF.
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Immediate versus deferred beta-blockade following thrombolytic therapy in patients with acute myocardial infarction. Results of the Thrombolysis in Myocardial Infarction (TIMI) II-B Study.
Robert Roberts,William J. Rogers,Hiltrud S. Mueller,Costas T. Lambrew,Daniel J. Diver,Hugh C. Smith,James T. Willerson,Genell L. Knatterud,Sandra A. Forman,Eugene R. Passamani +9 more
TL;DR: In appropriate postinfarction patients, beta-blockers are safe when given early after thrombolytic therapy and are associated with decreased myocardial ischemia and reinfarction in the first week but offer no benefit over late administration in improving ventricular function or reducing mortality.
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Coronary artery bypass grafting in severe left ventricular dysfunction: Excellent survival with improved ejection fraction and functional state
TL;DR: In patients with coronary artery disease and advanced ventricular dysfunction: 1) coronary artery bypass grafting can be performed relatively safely, 2) good medium-term survival is attained, 3) improvement in left ventricular function can be documented objectively after bypass grafts, 4) quality of life is improved (as reflected by improvement in anginal and congestive heart failure status), and 5) the internal mammary artery can safely be used as a conduit.
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Preoperative Positron Emission Tomographic Viability Assessment and Perioperative and Postoperative Risk in Patients With Advanced Ischemic Heart Disease
Felix Haas,Christoph Haehnel,Wolfgang Picker,Stephan G. Nekolla,Stefan Martinoff,Hans Meisner,Markus Schwaiger +6 more
TL;DR: In this article, the authors investigated whether determination of tissue viability by means of positron emission tomography (PET) before coronary artery bypass graft surgery (CABG) affects clinical outcome with respect to both in-hospital mortality and 1-year survival rate.
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Failure to Improve Left Ventricular Function After Coronary Revascularization for Ischemic Cardiomyopathy Is Not Associated With Worse Outcome
Habib Samady,John A. Elefteriades,Brian G. Abbott,Jennifer A. Mattera,Craig A. McPherson,Frans J. Th. Wackers +5 more
TL;DR: Lack of improvement of global LVEf after CABG is not associated with poorer outcome compared with that of patients with improved LVEF, presumably because effective revascularization of ischemic myocardium, even without improvement in ventricular function, protects against future infarction and death.
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The thrombolysis in myocardial infarction (TIMI) trial. Phase I findings
Journal ArticleDOI
Thrombolysis in Myocardial Infarction (TIMI) Trial, Phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge.
James H. Chesebro,Genell L. Knatterud,Robert Roberts,Jeffrey S. Borer,Lawrence S. Cohen,James E. Dalen,Harold T. Dodge,C K Francis,D. Hillis,P Ludbrook +9 more
TL;DR: In patients with acute myocardial infarction, rt-PA elicited reperfusion in twice as many occluded infarct-related arteries as compared with SK at each of seven serial observations during the first 90 min after onset of treatment.
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Effect of intravenous streptokinase on left ventricular function and early survival after acute myocardial infarction.
Harvey D. White,Robin M. Norris,Michael A. Brown,Morimasa Takayama,Andrew Maslowski,Nigel M. Bass,John A. Ormiston,Toby Whitlock +7 more
TL;DR: It is concluded that administration of intravenous streptokinase to patients with a first myocardial infarction results in improved left ventricular function and short-term survival.
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A Randomized Trial of Intracoronary Streptokinase in the Treatment of Acute Myocardial Infarction
Jeffrey L. Anderson,Hiram W. Marshall,Bruce E. Bray,Joan R. Lutz,Philip R. Frederick,Frank G. Yanowitz,Frederick L. Datz,Steven C. Klausner,Arthur D. Hagan +8 more
TL;DR: It is concluded that intracoronary streptokinase appears to have a beneficial effect on the early course of acute myocardial infarction.