Radiation Protection of Mouse Liver by 2-Mercaptopropionylglycine
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The MPG was found to provide ample protection to the liver leading to an accelerated recovery and restoring the normal structure by 4 weeks after irradiation.Abstract:
The present study is an attempt to investigate the protection imparted by MPG (2-mercaptopropionylglycine) to liver in Swiss albino mice against damages caused by external irradiation. The histopathological changes in the liver of a group of mice exposed to 1000 R of Co-60 gamma rays 15-30 minutes after an intraperitoneal injection of 20 mg/kg body weight of MPG were studied at different post-irradiation intervals. The results were compared with those received from a control group which was irradiated in the absence of the drug. The MPG was found to provide ample protection to the liver leading to an accelerated recovery and restoring the normal structure by 4 weeks after irradiation.read more
Citations
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Journal ArticleDOI
Radioprotective effect of 2-mercaptopropionylglycine on radiation-induced microsomal lipid peroxidation.
S.I. Ayene,P.N. Srivastava +1 more
TL;DR: The exogenous supply of Fe2+ during irradiation was found to eliminate the 'threshold dose' which has to be delivered before MPG shows an 'enhancement effect'.
Journal ArticleDOI
Radiation protection of bone marrow lymphocytes by 2-mercaptopropionylglycine (MPG).
TL;DR: The drug, MPG, when administered before irradiation, increases the radioresistance of bone marrow lymphocytes of mice to gamma rays and helps in promoting fast recovery, especially when exposed to sublethal dose.
Journal ArticleDOI
Radiation protection of pronormoblasts and normoblasts by 2-mercaptopropionylglycine (MPG)
M. R. Saini,P. Uma Devi +1 more
TL;DR: It is concluded that the drug protects the stem cells and thereby reduces the depletion of the regenerating pool which causes a more efficient and accelerated recovery.
Journal ArticleDOI
Protection of Mouse Liver by 2-Mercaptopropionylglycine Against Beta Radiations from Injected Tritiated Water
TL;DR: The hepatic damage was pronounced and the recovery was delayed as compared with experimental animals, and the increase in percentage of binucleate cells and abnormal nuclei was also more remarkable in the control animals.
Journal ArticleDOI
Effect of 2-Mercaptopropionylglycine and 2-Aminoethyl Isothiuronium Bromide Hydrobromide on Leucocytes in Peripheral Blood After Gamma Ray Exposure in Mice
A. Ghose,R. D. Pant +1 more
TL;DR: Two-Mercaptopropionyl glycine combined with two hundred mg/kg AET has not offered any extra radioprotection to peripheral blood leucocytes after 760R gamma exposure and the combination has been less effective than the respective AET dose given singly.
References
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Hepatic injury following irradiation--a morphologic study--.
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Roentgen-ray intoxication: disturbances in metabolism produced by deep massive doses of the hard roentgen rays
C. C. Hall,G. H. Whipple +1 more
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Histological changes produced by a single large injection of radioactive phosphorus (P32) in albino rats and in C3H mice.
B. Grad,C. E. Stevens +1 more
TL;DR: An attempt was made to discover the immediate effects of P32 on cytological structures and the location of the effects throughout the body by means of his tological studies.
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Experimental liver disease produced by X‐ray irradiation of the exposed organ
Adolph Bolliger,Keith Inglis +1 more
Journal ArticleDOI
A Comparison of the Chronic Effects of Irradiation upon the Normal, Damaged, and Regenerating Rat Liver
TL;DR: Radioisotope scanning methods have now allowed us to visualize defects in the liver parenchyma as the result of irradiation, and several recent reports have clearly shown that a segment of the liver included within the portal of irradation becomes nonfunctioning for a varied period of time.
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