Journal ArticleDOI
Radioimmunoassay of plasma estrone and estradiol.
TLDR
Estradiol-17β-succinyl-BSA was used as an antigen to produce antibodies to estradiol (E2), which was used in the development of a radioimmunoassay for E1 and E2 and did not cross react significantly with other steroids except estron.About:
This article is published in Steroids.The article was published on 1970-03-01. It has received 242 citations till now. The article focuses on the topics: Estrone & Radioimmunoassay.read more
Citations
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Journal ArticleDOI
Familial incomplete male pseudohermaphroditism, type 2. Decreased dihydrotestosterone formation in pseudovaginal perineoscrotal hypospadias.
Patrick C. Walsh,James D. Madden,Mary Jo Harrod,Joseph L. Goldstein,Paul C. MacDonald,Jean D. Wilson +5 more
TL;DR: The demonstration of markedly deficient dihydrotestosterone formation in slices of perineal skin, epididymis and phallus, is compatible with the fact that dihydotestosterone is the fetal hormone responsible for male differentiation of the external genitalia, iscompatible with the idea that androgen resistance in this syndrome is different from that in other androgen-resistant states.
Journal ArticleDOI
Endogenous Estrogen, Androgen, and Progesterone Concentrations and Breast Cancer Risk Among Postmenopausal Women
TL;DR: Circulating levels of sex steroid hormones may be most strongly associated with risk of ER+/PR+ breast tumors, but there were no statistically significant associations between this risk and the level of progesterone or sex hormone binding globulin.
Journal ArticleDOI
Explaining sex differences in dental caries prevalence: saliva, hormones, and "life-history" etiologies.
TL;DR: The results suggest that hormonal fluctuations can have a dramatic effect on the oral health of women, and constitute an important causal factor in explaining sex differences in caries rates.
Journal ArticleDOI
A radioimmunoassay for plasma testosterone.
TL;DR: The mean and range of plasma testosterone concentrations in normal men and women determined by this method were similar to those reported by other investigators using different methods.
Journal ArticleDOI
Effects of luteectomy and progesterone replacement therapy in early pregnant patients
TL;DR: It is concluded that the evolution of intrauterine pressure and oxytocin response culminating in abortion can be provoked during early pregnancy by luteectomy-induced progesterone withdrawal which only occurs prior to an advanced luteoplacental shift in the site of progester one synthesis.
References
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Journal ArticleDOI
Solid-phase radioimmunoassay in antibody-coated tubes.
K. J. Catt,Geoffrey W. Tregear +1 more
TL;DR: The adsorption of antibody to polymeric surfaces has been used to develop a new method of solid-phase radioimmunoassay that is simple, rapid, inexpensive, and suitable for automation.
Journal ArticleDOI
Biologically Active Water-insoluble Protein Polymers 1. THEIR USE FOR ISOLATION OF ANTIGENS AND ANTIBODIES
TL;DR: Evidence has been obtained to show that polymerization has occurred and that the protein molecules are linked covalently to one another, and to remove contaminating antigen and antibody proteins from solutions.
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Plasma precursors of estrogen. I. Extent of conversion of plasma delta-4-androstenedione to estrone in normal males and nonpregnant normal, castrate and adrenalectomized females.
TL;DR: Results indicate that in the young adult female an “extraglandular” source of estrone of approximately 44 μg/day may arise from plasma borne Δ4-androstenedione.
Journal ArticleDOI
Concentration of unconjugated estrone and estradiol in peripheral plasma in nonpregnant women throughout the menstrual cycle, castrate and postmenopausal women and in men.
David T. Baird,Amelia Guevara +1 more
TL;DR: The concentration of estradiol showed a biphasic curve throughout the menstrual cycle rising from a mean value of 2.9±0.7 during menstruation to a maximum of 31.8±2.7 around midcycle, indicating the increasing predominance of estra...