Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes (RABBIT 2 trial).
Guillermo E. Umpierrez,Dawn Smiley,Ariel Zisman,Luz M. Prieto,Andres Palacio,Miguel Ceron,Alvaro Puig,Roberto Mejia +7 more
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TLDR
In this paper, the optimal management of hyperglycemia in non-intensive care unit patients with type 2 diabetes was studied, and a prospective, multicenter, randomized trial was conducted to compare the efficacy and safety of a basal-bolus insulin regimen with that of sliding-scale regular insulin (SSI) in patients with Type 2 diabetes.Abstract:
OBJECTIVE —We sought to study the optimal management of hyperglycemia in non–intensive care unit patients with type 2 diabetes, as few studies thus far have focused on the subject. RESEARCH DESIGN AND METHODS —We conducted a prospective, multicenter, randomized trial to compare the efficacy and safety of a basal-bolus insulin regimen with that of sliding-scale regular insulin (SSI) in patients with type 2 diabetes. A total of 130 insulin-naive patients were randomized to receive glargine and glulisine ( n = 65) or a standard SSI protocol ( n = 65). Glargine was given once daily and glulisine before meals at a starting dose of 0.4 units · kg −1 · day −1 for blood glucose 140–200 mg/dl or 0.5 units · kg −1 · day −1 for blood glucose 201–400 mg/dl. SSI was given four times per day for blood glucose >140 mg/dl. RESULTS —The mean admission blood glucose was 229 ± 6 mg/dl and A1C 8.8 ± 2%. A blood glucose target of P 240 mg/dl. There were no differences in the rate of hypoglycemia or length of hospital stay. CONCLUSIONS —Treatment with insulin glargine and glulisine resulted in significant improvement in glycemic control compared with that achieved with the use of SSI alone. Our study indicates that a basal-bolus insulin regimen is preferred over SSI in the management of non–critically ill, hospitalized patients with type 2 diabetes.read more
Citations
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Journal ArticleDOI
Standards of Medical Care in Diabetes—2010
TL;DR: These standards of care are intended to provide clinicians, patients, researchers, payors, and other interested individuals with the components of diabetes care, general treatment goals, and tools to evaluate the quality of care.
Journal ArticleDOI
American Association of Clinical Endocrinologists and American Diabetes Association Consensus Statement on Inpatient Glycemic Control
Etie S. Moghissi,Mary T. Korytkowski,Monica DiNardo,Daniel Einhorn,Richard Hellman,Irl B. Hirsch,Silvio E. Inzucchi,Faramarz Ismail-Beigi,M. Sue Kirkman,Guillermo E. Umpierrez +9 more
TL;DR: Recommendations from the ACE and the ADA generally endorsed tight glycemic control in critical care units and for patients in general medical and surgical units, where RCT evidence regarding treatment targets was lacking, glycemic goals similar to those advised for outpatients were advocated.
Journal ArticleDOI
Management of Hyperglycemia in Hospitalized Patients in Non-Critical Care Setting: An Endocrine Society Clinical Practice Guideline
Guillermo E. Umpierrez,Richard Hellman,Mary T. Korytkowski,Mikhail Kosiborod,Gregory A. Maynard,Victor M. Montori,Jane Jeffrie Seley,Greet Van den Berghe +7 more
TL;DR: This evidence-based guideline provides recommendations for practical, achievable, and safe glycemic targets and describes protocols, procedures, and system improvements required to facilitate the achievement of glycemic goals in patients with hyperglycemia and diabetes admitted in non-critical care settings.
Standards of Medical Care in Diabetes—2009
TL;DR: These standards of care are intended to provide clinicians, patients, researchers, payors, and other interested individuals with the components of diabetes care, treatment goals, and tools to evaluate the quality of care.
References
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Journal ArticleDOI
Intensive Insulin Therapy in Critically Ill Patients
Greet Van den Berghe,Pieter Wouters,Frank Weekers,Charles Verwaest,Frans Bruyninckx,Miet Schetz,Dirk Vlasselaers,Patrick Ferdinande,Peter Lauwers,Roger Bouillon +9 more
TL;DR: Intensive insulin therapy to maintain blood glucose at or below 110 mg per deciliter reduces morbidity and mortality among critically ill patients in the surgical intensive care unit.
Journal ArticleDOI
Intensive insulin therapy in the medical ICU.
Greet Van den Berghe,Alexander Wilmer,Greet Hermans,Wouter Meersseman,Pieter Wouters,Ilse Milants,Eric Van Wijngaerden,Herman Bobbaers,Roger Bouillon +8 more
TL;DR: Intensive insulin therapy significantly reduced morbidity but not mortality among all patients in the medical ICU, and the risk of subsequent death and disease was reduced in patients treated for three or more days.
Journal ArticleDOI
Hyperglycemia: An Independent Marker of In-Hospital Mortality in Patients with Undiagnosed Diabetes
Guillermo E. Umpierrez,Scott D. Isaacs,Niloofar Bazargan,Xiangdong You,Leonard M. Thaler,Abbas E. Kitabchi +5 more
TL;DR: In this article, the authors determined the prevalence of in-hospital hyperglycemia and determined the survival and functional outcome of patients with and without a history of diabetes in patients admitted to the Georgia Baptist Medical Center.
Journal ArticleDOI
Management of diabetes and hyperglycemia in hospitals.
Stephen Clement,Susan S. Braithwaite,Michelle F. Magee,Andrew J. Ahmann,Elizabeth P. Smith,Rebecca G. Schafer,Irl B. Hirsch +6 more
TL;DR: The purpose of this technical review is to evaluate the evidence relating to the management of hyperglycemia in hospitals, with particular focus on the issue of glycemic control and its possible impact on hospital outcomes.
Journal ArticleDOI
Association Between Hyperglycemia and Increased Hospital Mortality in a Heterogeneous Population of Critically Ill Patients
TL;DR: Even a modest degree of hyperglycemia occurring after intensive care unit admission was associated with a substantial increase in hospital mortality in patients with a wide range of medical and surgical diagnoses, adding predictive power above that achieved by APACHE II scores alone.
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