Journal ArticleDOI
Reactions with 2‐mercaptopyrimidines. Synthesis of some new thiazolo[3,2‐a]‐ and triazolo[4,3‐a]pyrimidines
TLDR
Alkylation of 5-cyano-4-oxo-6-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine I with methyl iodide, chloroacetic acid or 3-chloro-2,4 -pentanedione, afforded the S-alkyl derivatives IIa-c. 2-Carboxymethylthio and 2-(2′,4′-dioxopentan-3-ylthio) derivatives IIb and IIc could be cyclised byAbout:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 1987-11-01. It has received 29 citations till now. The article focuses on the topics: Acetic anhydride & Chloroacetic acid.read more
Citations
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Journal ArticleDOI
Synthesis, Antioxidant, Antituomer Activities of Some New Thiazolopyrimidines, Pyrrolothiazolopyrimidines and Triazolopyrrolothiazolopyrimidines Derivatives
TL;DR: In this paper, reaction of 6-amino-2-thiouracil with ethyl bromoacetate yielded the pyrrolothiazolopyrimidine derivative.
Journal ArticleDOI
Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities.
TL;DR: Several derivatives of pyrrolo [2, 3-d] pyrimidine-2 and/or 4 thione derivatives, showed a promising anti-inflammatory activity in compared to ibuprofen.
Journal ArticleDOI
Synthesis, in vitro antimicrobial and in vivo antitumor evaluation of novel pyrimidoquinolines and its nucleoside derivatives
TL;DR: The new quinolines derivatives were evaluated for their anticancer activity toward human cancer cell lines by the National Cancer Institute and had excellent growth inhibition activity, having LD(50) values in the low micromolar to nanomolar concentration range.
Book ChapterDOI
The Chemistry of 1,2,4-Triazolopyrimidines I: 1,2,4-Triazolo[4,3-a]Pyrimidines
TL;DR: This chapter concludes by discussing that many members of the 1,2,4-triazoIo[4,3-c]pyrimidines are shown to possess very interesting biological activities and medicinal applications.
Book ChapterDOI
1,2,4-Triazolo- and Tetrazolo[x,y-z]pyrimidines
TL;DR: In this article, the chemistry, biological significance, and uses of 1,2,4-triazolo-and tetrazolo-[x,y-zl pyrimidines] are reviewed.
References
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Journal ArticleDOI
A one-step synthesis of 4-oxo-2-thioxopyrimidine derivatives by the ternary condensation of ethyl cyanoacetate, aldehydes, and thiourea
Journal ArticleDOI
Reactions with the Arylhydrazones of some α-cyanoketones
TL;DR: In this article, Diazomethane reacts with the arylhydrazones of mesoxalic acid dinitrile 1a-c and of ethyl α-cyanoglyoxalate 2b, d-g to yield the methylarylhydrazone 3a−c and 4a−e respectively.
Journal ArticleDOI
Synthesen mit heterocyclischen Aminen, I. Reaktionen des 3(5)‐Amino‐pyrazols mit α,β‐ungesättigten Estern. Darstellung und Charakterisierung isomerer Oxo‐dihydro‐pyrazolo‐pyrimidine
TL;DR: In this paper, the authors discuss the mechanism of formation of the isomeric oxodihydropyrazolo[l,5-a]-pyrimidines and the spectra and mechanism of the formation of 3(5)-Aminopyrazole with α.β-Unsaturated Esters.
Journal ArticleDOI
Proton magnetic resonance spectra of some tetrazoles, triazoles, and tetrazolium and triazolium salts
Lester A. Lee,J. W. Wheeler +1 more
Journal ArticleDOI
Studies on 3,5-pyrazolidinediones. IV. Addition of 4-Arylazo-3,5-pyrazolidinediones to Ethyl Acrylate
TL;DR: In this paper, arylazomalonic acid dihydrazide was found to react with acrylonitrile to yield the corresponding 1-substituted 2β-cyanoethyl derivatives V and VI respectively.