Recent trends in physician diagnosed COPD in women and men in the UK
Joan B. Soriano,W C Maier,Peter J. Egger,George Visick,Bharat Thakrar,Jennie Sykes,Neil B. Pride +6 more
TLDR
While prevalence rates of COPD in the UK seem to have peaked in men, they are continuing to rise in women, and this trend, together with the ageing of the population and the long term cumulative effect of pack-years of smoking in women is likely to increase the present burden of COPd in theUK.Abstract:
Background—Recent trends in physician diagnosed chronic obstructive pulmonary disease (COPD) in the UK were estimated, with a particular focus on women. Methods—A retrospective cohort of British patients with COPD was constructed from the General Practice Research Database (GPRD), a large automated database of UK general practice data. Prevalence and all-cause mortality rates by sex, calendar year, and severity of COPD, based on treatment only, were estimated from January 1990 to December 1997. Results—A total of 50 714 incident COPD patients were studied, 23 277 (45.9%) of whom were women. From 1990 to 1997 the annual prevalence rates of physician diagnosed COPD in women rose continuously from 0.80% (95% CI 0.75 to 0.83) to 1.36% (95% CI 1.34 to 1.39), (p for trend <0.01), rising to the rate observed in men in 1990. Increases in the prevalence of COPD were observed in women of all ages; in contrast, a plateau was observed in the prevalence of COPD in men from the mid 1990s. Allcause mortality rates were higher in men than in women (106.8 versus 82.2 per 1000 person-years), with a consistently increased relative risk in men of 1.3 even after controlling for the severity of COPD. Significantly increased mortality rates were also observed in adults aged less than 65 years. The mean age at death was 76.5 years; patients with severe COPD died an average of three years before those with mild disease (p<0.01) and four years before the age and sex matched reference population. Conclusions—While prevalence rates of COPD in the UK seem to have peaked in men, they are continuing to rise in women. This trend, together with the ageing of the population and the long term cumulative eVect of pack-years of smoking in women, is likely to increase the present burden of COPD in the UK. (Thorax 2000;55:789‐794)read more
Citations
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Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary.
Jørgen Vestbo,Suzanne S. Hurd,Alvar Agusti,Paul W. Jones,Claus Vogelmeier,Antonio Anzueto,Peter J. Barnes,Leonardo M. Fabbri,Fernando J. Martinez,Masaharu Nishimura,Robert A. Stockley,Don D. Sin,Roberto Rodriguez-Roisin +12 more
TL;DR: It is recommended that spirometry is required for the clinical diagnosis of COPD to avoid misdiagnosis and to ensure proper evaluation of severity of airflow limitation.
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Global initiative for chronic obstructive lung disease.
Lynn B. Gerald,William C. Bailey +1 more
TL;DR: Representatives from many countries serve as a network for the dissemination and implementation of programs for diagnosis, management, and prevention of COPD.
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Global burden of COPD: systematic review and meta-analysis
Ronald J. Halbert,J.L. Natoli,J.L. Natoli,Anacleto Gano,E. Badamgarav,A. S. Buist,David M. Mannino +6 more
TL;DR: The aim of this study was to quantify the global prevalence of chronic obstructive pulmonary disease by means of a systematic review and random effects meta-analysis and population-based prevalence estimates published during the period 1990–2004.
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Validation and validity of diagnoses in the General Practice Research Database: a systematic review
TL;DR: The range of methods used to validate diagnoses in the General Practice Research Database (GPRD) are investigated, to summarize findings and to assess the quality of these validations.
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Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: National Heart, Lung, and Blood Institute and World Health Organization Global Initiative for Chronic Obstructive Lung Disease (GOLD): executive summary.
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