Recombinant factor VIIa for life-threatening post-partum haemorrhage
Jouni Ahonen,Ritva Jokela +1 more
TLDR
In 11 women there was a partial or good response to rFVIIa administration, while in one there was no response, and in the four women undergoing a subsequent selective arterial embolization, the bleeding was significantly reduced although not completely stopped.Abstract:
The treatment of life-threatening post-partum haemorrhage (PPH) still remains challenging, and hysterectomy may be required to control the bleeding. We present 12 cases of severe PPH treated with recombinant factor VIIa (rFVIIa). We briefly describe the causes of the haemorrhage and the medical and surgical interventions before rVIIa administration. In 11 women there was a partial or good response to rFVIIa administration, while in one there was no response. In the four women undergoing a subsequent selective arterial embolization, the bleeding was significantly reduced although not completely stopped. From our experience with these 12 cases, and from previously reported cases, the use of rFVIIa may be of benefit in life-threatening PPH. However, treatment with rFVIIa, in addition to standard surgical and medical interventions, may not be definitive in every patient and a selective arterial embolization may be needed.read more
Citations
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Journal ArticleDOI
Management of severe perioperative bleeding Guidelines from the European Society of Anaesthesiology
Sibylle A. Kozek-Langenecker,Arash Afshari,Pierre Albaladejo,Cesar Aldecoa Alvarez Santullano,Edoardo De Robertis,Daniela Filipescu,Dietmar Fries,Thorsten Haas,Georgina Imberger,Matthias Jacob,Marcus D. Lancé,Juan V. Llau,Susan Mallett,Jens Meier,Niels Rahe-Meyer,Charles Marc Samama,Andrew Smith,Cristina Solomon,Philippe Van der Linden,Anne Wikkelsø,Patrick Wouters,Piet Wyffels +21 more
TL;DR: These guidelines are intended to provide an overview of current knowledge on the subject with an assessment of the quality of the evidence in order to allow anaesthetists throughout Europe to integrate this knowledge into daily patient care wherever possible.
Journal ArticleDOI
European Resuscitation Council guidelines for resuscitation 2005. Section 7. Cardiac arrest in special circumstances.
Jasmeet Soar,Charles D. Deakin,Jerry P. Nolan,Gamal Abbas,A. Alfonzo,Anthony J. Handley,David Lockey,Gavin D. Perkins,K Thies +8 more
TL;DR: Electrolyte abnormalities can cause cardiac rrhythmias or cardiopulmonary arrest, and precise values that trigger treatment deciions will depend on the patient’s clinical conition and the rate of change of the electrolyte alues.
European Resuscitation Council (ERC) Guidelines for Resuscitation 2005
Journal ArticleDOI
Peripartum hysterectomy in the UK: management and outcomes of the associated haemorrhage
TL;DR: For each woman who dies in the UK following peripartum hysterectomy, more than 150 survive and the associated haemorrhage is managed in a variety of ways and not universally according to existing guidelines.
Journal ArticleDOI
Recombinant factor VIIa for the prevention and treatment of bleeding in patients without haemophilia
TL;DR: The effectiveness of rFVIIa when used therapeutically to control active bleeding or prophylactically to prevent (excessive) bleeding in patients without haemophilia is assessed.
References
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Journal ArticleDOI
Treatment of traumatic bleeding with recombinant factor VIIa.
TL;DR: Administration of recombinant factor VIIa immediately corrected the coagulopathy and bleeding stopped and surgery failed to stop life-threatening bleeding caused by injury complicated by severe coagULopathy.
Journal ArticleDOI
Recombinant activated factor VII for adjunctive hemorrhage control in trauma.
Uri Martinowitz,Gili Kenet,Eran Segal,J. Luboshitz,Aharon Lubetsky,Jørgen Ingerslev,Mauricio Lynn +6 more
TL;DR: The results of this report suggest that in trauma patients rFVIIa may play a role as an adjunctive hemostatic measure, in addition to surgical he mostatic techniques, and provides the motivation for controlled animal and clinical trials.
Journal ArticleDOI
Effect of recombinant activated factor VII on perioperative blood loss in patients undergoing retropubic prostatectomy: a double-blind placebo-controlled randomised trial
Philip W. Friederich,Christiaan P Henny,Embert J. Messelink,Mark G Geerdink,Tymen T. Keller,Karl-Heinz Kurth,Harry R. Büller,Marcel Levi +7 more
TL;DR: An injection of recombinant factor VIIa can reduce perioperative blood loss and eliminate the need for transfusion in patients undergoing major surgery.
Journal ArticleDOI
The treatment of bleeding in acquired haemophilia with recombinant factor VIIa: a multicentre study.
TL;DR: In this article, the authors used Recombinant Factor VIIa (RVIIIa) as first-line therapy for 14 bleeding episodes and as salvage-therapy for 60 episodes which failed to respond to blood-product therapy given for a median of four days (range 1-21 days).
Journal ArticleDOI
The effect of fibrin structure on fibrinolysis.
TL;DR: It is shown that thin fibrin fibers have a decreased rate of conversion of plasminogen toplasmin by tissue plasmineogen activator and that thinfibrin fiber are lysed more slowly than thick fibrIn fibers.
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