Journal ArticleDOI
Recovery of Herpes-Simplex Virus from Human Trigeminal Ganglions
Baringer,Swoveland P +1 more
TLDR
In six of seven patients, herpes-simplex virus was recovered from trigeminal ganglions obtained at autopsy from unselected cadavers less than 12 hours after death and maintained in culture for up to two weeks after death.Abstract:
In six of seven patients, herpes-simplex virus was recovered from trigeminal ganglions obtained at autopsy from unselected cadavers less than 12 hours after death and maintained in culture for 10 to 45 days. The virus was not obtained from similarly handled cultures of trigeminal nerve or root from the same patients. The identity of the virus was confirmed by fluorescent-antibody and neutralization tests and by electron microscopy. The results indicate that herpes-simplex virus is present in a high proportion of human trigeminal ganglions and suggest this as a possible site of latent virus causing recurrent oral infection.read more
Citations
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Journal ArticleDOI
Herpes Simplex Viruses
TL;DR: Drug resistance was considered rare and resistant isolates were thought to be less pathogenic until a series of acyclovir-resistant HSV isolates from patients with AIDS were characterized.
Journal ArticleDOI
Herpes simplex virus infections
TL;DR: This review provides a contemporary interpretation of the biological properties, function, epidemiology, and treatment of HSV diseases.
Journal Article
Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature.
TL;DR: In this paper, a review of the acquired immunodeficiency syndrome (AIDS) the authors have evaluated a total of 352 homosexual patients with AIDS or generalized lymphadenopathy managed at the University of California San Francisco (UCSF) between 1979 and 1984.
Journal ArticleDOI
Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): Experience at UCSF and review of the literature
TL;DR: In light of the protean behavior of AIDS and the problems related to the clinical, radiological, and serological diagnosis of the unusual and varied associated nervous system diseases, patients with AIDS and neurological complaints require a rigorous and detailed evaluation.
Journal ArticleDOI
Infections with herpes simplex viruses (1).
Lawrence Corey,Patricia G. Spear +1 more
TL;DR: This review concludes that there have been substantial advances in the knowledge of the clinical manifestations, pathogenesis, and treatment of herpes simplex virus infections in the 12 years since the last review.
References
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Journal ArticleDOI
Herpesvirus hominis: Isolation from Human Trigeminal Ganglion
TL;DR: Observations support the concept that latent infection of sensory ganglia may be the source of virus in recurrent herpetic disease in man.
Journal ArticleDOI
Latent herpes simplex virus from trigeminal ganglia of rabbits with recurrent eye infection.
TL;DR: It is reported that herpes simplex virus does indeed induce latent infection in trigeminal ganglia of rabbits presenting recurrent eye infection, and infectious virus could not be recovered directly when ganglia were established as organ cultures in vitro.
Journal ArticleDOI
Activation of latent herpes simplex by trigeminal sensory-root section.
TL;DR: The frequently made clinical observation that trigeminal sensory-root section for trigemINAL neuralgia is often followed by facial herpes prompted the study of this phenomenon in some patients.
Journal ArticleDOI
Experimental herpes simplex encephalitis: early neuropathologic changes.
J. R. Baringer,J. F. Griffith +1 more
Journal ArticleDOI
Electron microscopy of the gasserian ganglion in trigeminal neuralgia.
TL;DR: The pathogenesis of trigeminal neuralgia has remained an enigma, and for degenerative changes due to aging 165 or to occult ganglionic disease 13~ must be differentiated from tissue artifacts due to manipulation and to fixation.