Journal ArticleDOI
Latent herpes simplex virus in spinal ganglia of mice.
Jack G. Stevens,Margery L. Cook +1 more
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Herpes simplex virus establishes a persistent, latent infection in spinal ganglia after mice have recovered from posterior paralysis and is replicated when these ganglia are explanted and maintained as organ cultures in vitro.Abstract:
Herpes simplex virus establishes a persistent, latent infection in spinal ganglia after mice have recovered from posterior paralysis. Infectious virus is replicated when these ganglia are explanted and maintained as organ cultures in vitro.read more
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Herpes Simplex Viruses
TL;DR: Drug resistance was considered rare and resistant isolates were thought to be less pathogenic until a series of acyclovir-resistant HSV isolates from patients with AIDS were characterized.
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Herpes simplex virus infections
TL;DR: This review provides a contemporary interpretation of the biological properties, function, epidemiology, and treatment of HSV diseases.
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RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons.
TL;DR: In initial attempts to define the molecular events responsible for the latent state of herpes simplex virus, in situ hybridization was utilized to search for virally encoded RNA transcripts in latently infected sensory neurons, finding only RNA transcripts hybridizing to the ICP-0 probe were detected.
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Infections with herpes simplex viruses (1).
Lawrence Corey,Patricia G. Spear +1 more
TL;DR: This review concludes that there have been substantial advances in the knowledge of the clinical manifestations, pathogenesis, and treatment of herpes simplex virus infections in the 12 years since the last review.
Journal ArticleDOI
Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo
Hanspeter Pircher,Demetrius Moskophidis,Urs Hoffmann Rohrer,Kurt Bürki,Hans Hengartner,Rolf M. Zinkernagel +5 more
TL;DR: It is now shown that viruses can in principle escape the immunosurveillance of virus-specific cytotoxic T cells by mutations that alter the relevant T-cell epitope.
References
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Journal ArticleDOI
The pathogenesis of herpes virus encephalitis : i. virus pathways to the nervous system of suckling mice demonstrated by fluorescent antibody staining
TL;DR: The pathogenesis of herpes simplex virus encephalitis and myelitis was studied in suckling mice using routine titration procedures and fluorescent antibody staining for the identification of infected cells and there was no evidence of axonal spread of virus in the host-virus system studied.
Journal ArticleDOI
Restriction of herpes simplex virus by macrophages. An analysis of the cell-virus interaction.
Jack G. Stevens,Margery L. Cook +1 more
TL;DR: An analysis of virus-specified macromolecular syntheses in infected macrophages indicated that the major viral-specific proteins were induced in macrophage cultures, and it is suggested that an error in DNA metabolism may be the primary cause of restriction.
Journal Article
Transmission of the Virus of Herpes Febrilis along Nerves in experimentally infected Rabbits.
Journal ArticleDOI
The progression of herpes simplex virus to the central nervous system of the mouse.
TL;DR: It appears that invasion of the central nervous system takes place only by way of the peripheral nerve, and paralysis is not prevented by circulating neutralizing antibody given 18 hours after inoculation.