Journal ArticleDOI
Infections with herpes simplex viruses (1).
Lawrence Corey,Patricia G. Spear +1 more
TLDR
This review concludes that there have been substantial advances in the knowledge of the clinical manifestations, pathogenesis, and treatment of herpes simplex virus infections in the 12 years since the last review.Abstract:
IN the 12 years since the last review of herpes simplex virus (HSV) infections in these pages,1 there have been substantial advances in our knowledge of the clinical manifestations, pathogenesis, a...read more
Citations
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PatentDOI
Herpes simplex virus 1 entry into cells mediated by a novel member of the tnf/ngf receptor family
TL;DR: HVEM, the first identified mediator of HSV entry, is a new member of the TNF/NGF receptor family and showed to mediate the entry of several wild-type HSV strains of both serotypes.
Journal ArticleDOI
Herpes Simplex Virus Type 2 in the United States, 1976 to 1994
D T Fleming,Geraldine M. McQuillan,Robert E. Johnson,Andre J. Nahmias,Sevgi O. Aral,Francis K. Lee,M E St Louis +6 more
TL;DR: The seroprevalence of HSV-2 in persons 12 years of age or older in the United States was 21.9 percent (95 percent confidence interval, 20.2 to 23.6 percent), corresponding to 45 million infected people in the noninstitutionalized civilian population.
Journal ArticleDOI
A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry
Deepak Shukla,Jian Liu,Peter Blaiklock,Nicholas W. Shworak,Nicholas W. Shworak,Xiaomei Bai,Jeffrey D. Esko,Gary H. Cohen,Roselyn J. Eisenberg,Robert D. Rosenberg,Robert D. Rosenberg,Patricia G. Spear +11 more
TL;DR: It is shown that heparan sulfate modified by a subset of the multiple D-glucosaminyl 3-O-sulfotransferase isoforms provides sites for the binding of a third viral glycoprotein, gD, and for initiation of HSV-1 entry.
Journal ArticleDOI
The Medical Review Article: State of the Science
TL;DR: It is indicated that current medical reviews do not routinely use scientific methods to identify, assess, and synthesize information.
Journal ArticleDOI
Glycoprotein-D-adjuvant vaccine to prevent genital herpes.
Lawrence R. Stanberry,Spotswood L. Spruance,Anthony L. Cunningham,David I. Bernstein,Adrian Mindel,Stephen L. Sacks,Stephen K. Tyring,Fred Y. Aoki,Moncef Slaoui,Martine Denis,Pierre Vandepapelière,Gary Dubin +11 more
TL;DR: Two double-blind, randomized trials of a herpes simplex virus type 2 (HSV-2) glycoprotein-D-subunit vaccine with alum and 3-O-deacylated-monophosphoryl lipid A in subjects whose regular sexual partners had a history of genital herpes suggest that the glycop Protein D vaccine has efficacy against genital herpes in women who are seronegative for both HSV-1 and HSV -2 at base line but not in those
References
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Journal ArticleDOI
Severe Acquired Immunodeficiency in Male Homosexuals, Manifested by Chronic Perianal Ulcerative Herpes Simplex Lesions
Frederick P. Siegal,Carlos Lopez,G S Hammer,Arthur E. Brown,S.J. Kornfeld,Jonathan W. M. Gold,J. Hassett,S.Z. Hirschman,Charlotte Cunningham-Rundles,B.R. Adelsberg +9 more
TL;DR: Four homosexual men presented with gradually enlarging perianal ulcers, from which herpes simplex virus was cultured, and were found to have depressed cell-mediated immunity, as evidenced by skin anergy, lymphopenia, and poor or absent responses to plant lectins and antigens in vitro.
Journal ArticleDOI
Genital herpes simplex virus infections: clinical manifestations, course, and complications.
TL;DR: The clinical course and complications of 268 patients with first episodes and 362 with recurrent episodes of genital herpes infection were reviewed, and the major concerns were the frequency of recurrences and fear of transmitting infection to partners or infants.
Journal ArticleDOI
Vidarabine versus Acyclovir Therapy in Herpes Simplex Encephalitis
Richard J. Whitley,Charles A. Alford,Martin S. Hirsch,Robert T. Schooley,James P. Luby,Fred Y. Aoki,Daniel F. Hanley,Andre J. Nahmias,Seng-Jaw Soong +8 more
TL;DR: It is concluded that acyclovir is currently the treatment of choice for biopsy-proved herpes simplex encephalitis and patients under 30 years of age and with a Glasgow coma score above 10 had the best outcome with acy Clovir treatment.
Journal ArticleDOI
Recovery of Herpes-Simplex Virus from Human Trigeminal Ganglions
Baringer,Swoveland P +1 more
TL;DR: In six of seven patients, herpes-simplex virus was recovered from trigeminal ganglions obtained at autopsy from unselected cadavers less than 12 hours after death and maintained in culture for up to two weeks after death.
Journal ArticleDOI
Adenine Arabinoside Therapy of Biopsy-Proved Herpes Simplex Encephalitis
Richard J. Whitley,Seng-Jaw Soong,Raphael Dolin,George J. Galasso,Lawrence T. Ch'ien,Charles A. Alford +5 more
TL;DR: Adenine arabinoside (vidarabine) was used for treatment of Type 1 herpes simplex encephalitis in a placebo-controlled study as mentioned in this paper, which reduced mortality from 70 to 28 per cent (P = 0.03).