Journal ArticleDOI
Recurrence of hyperprolactinemia after selective transsphenoidal adenomectomy in women with prolactinoma.
TLDR
It is concluded that recurrence of hyperprolactinemia after successful surgery is frequent but delayed, and the immediate postoperative level of plasma prolactin was significantly lower in patients in whom normal prolactinema was maintained than in those who relapsed.Abstract:
To assess the long-term prognosis for women with prolactinoma after selective transsphenoidal adenomectomy, we followed 44 patients for 62±15 years Group 1 (28 patients) had microprolactinomas, and Group 2 (16 patients) had macroprolactinomas After surgery, normal plasma prolactin levels, resumption of menses, and cessation of galactorrhea were observed in 24 Group 1 patients (85 per cent) and 5 Group 2 patients (31 per cent) Hyperprolactinemia recurred in 12 of the 24 Group 1 patients and in 4 of the 5 Group 2 patients after 4±13 and 25±16 years of remission, respectively There was no radiologic evidence of tumor recurrence in any patient, and no relation was found between the occurrence of pregnancy after surgery and the recurrence of hyperprolactinemia Clinical and biologic features before surgery could not predict the long-term outcome However, the immediate postoperative level of plasma prolactin was significantly lower in patients in whom normal prolactinemia (64±11 ng per millread more
Citations
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Journal ArticleDOI
Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline
Shlomo Melmed,Felipe F. Casanueva,Andrew R. Hoffman,David L. Kleinberg,Victor M. Montori,Janet A. Schlechte,John A.H. Wass +6 more
TL;DR: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the strength of recommendations and the quality of evidence for diagnosis and treatment of hyperprolactinemia.
Journal ArticleDOI
Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1)
Rajesh V. Thakker,Paul J. Newey,Gerard V Walls,John P. Bilezikian,Henning Dralle,Peter R. Ebeling,Shlomo Melmed,Akihiro Sakurai,Francesco Tonelli,Maria Luisa Brandi +9 more
TL;DR: It is recommended that MEN1 patients and their families should be cared for by multidisciplinary teams comprising relevant specialists with experience in the diagnosis and treatment of patients with endocrine tumors.
Journal ArticleDOI
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer
Gary L. Francis,Steven G. Waguespack,Andrew J. Bauer,Peter Angelos,Salvatore Benvenga,Janete M. Cerutti,Catherine A. Dinauer,Jill Hamilton,Ian D. Hay,Markus Luster,Marguerite T. Parisi,Marianna Rachmiel,Geoffrey B. Thompson,Shunichi Yamashita +13 more
TL;DR: These inaugural guidelines provide recommendations for the evaluation and management of thyroid nodules in children and adolescents, including the role and interpretation of ultrasound, fine-needle aspiration cytology, and the management of benign nodules.
Journal ArticleDOI
Advances in the treatment of prolactinomas.
TL;DR: A critical analysis of the efficacy and safety of the various modes of therapy available for the treatment of patients with prolactinomas with an emphasis on challenging situations is provided, a discussion of the data regarding withdrawal of medical therapy, and a foreshadowing of novel approaches to therapy that may become available in the future.
Journal ArticleDOI
Clinical factors involved in the recurrence of pituitary adenomas after surgical remission: a structured review and meta-analysis
TL;DR: The postoperative basal hormone level is the most important predictor for recurrence in functioning adenomas, while in NFA no single convincing factor could be identified and a low postoperative hormone concentration was a prognostically favorable factor.
References
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Journal ArticleDOI
A Radioimmunoassay for Human Prolactin
TL;DR: The concentration of prolactin in the serum of normal children and adults of either sex was usually below 30 ng/ml, while very high concentrations were observed in newborn infants, and during pregnancy, the concentration rose progressively from an average of 30 ng-ml in the first trimester to 200 ng-ML at term.
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Detection, evaluation, and treatment of pituitary microadenomas in patients with galactorrhea and amenorrhea
TL;DR: It is concluded that sellar polytomography in women with hyperprolactinemia is a useful technique technique for the diagnosis of pituitary adenomas, a lesion which may occur more frequently than previously realized.
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Prolactin-secreting pituitary adenomas: transsphenoidal microsurgical treatment.
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Pregnancy, prolactin, and pituitary tumours.
TL;DR: Nine pregnancies are described in patients with pituitary tumours who had definite radiological evidence of a pituitsary tumour and no evidence of acromegaly or Cushing's disease and were treated with drugs to achieve pregnancy.
Journal ArticleDOI
Prolactin secreting tumors. Endocrine status before and after surgery in 33 women.
TL;DR: Peri-operative estimation of PRL plasma levels showed a fast return to normal levels in group I patients, and no pituitary deficiency observed after trans-sphenoidal removal of the tumor.