Journal ArticleDOI
Reduced Iodinated Contrast Media Administration in Coronary CT Angiography on a Clinical Photon-Counting Detector CT System
Шаамирова Юлдузхон Кабильджановна,Dan Yu,Saeideh Maleki Farahani,Shvydkoy, Roman,Heather Julie Wallace +4 more
TLDR
In this paper , the authors evaluated strategies to reduce contrast media volumes for coronary computed tomography (CT) angiography on a clinical first-generation dual-source photon-counting detector (PCD)-CT system using a dynamic circulation phantom.Abstract:
The aim of this study was to evaluate strategies to reduce contrast media volumes for coronary computed tomography (CT) angiography on a clinical first-generation dual-source photon-counting detector (PCD)-CT system using a dynamic circulation phantom.Coronary CT angiograph is an established method for the assessment of coronary artery disease that relies on the administration of iodinated contrast media. Reduction of contrast media volumes while maintaining diagnostic image quality is desirable. In this study, a dynamic phantom containing a 3-dimensional-printed model of the thoracic aorta and coronary arteries was evaluated using a clinical contrast injection protocol with stepwise reduced contrast agent concentrations (100%, 75%, 50%, 40%, 30%, and 20% contrast media content of the same 50 mL bolus, resulting in iodine delivery rates of 1.5, 1.1, 0.7, 0.6, 0.4 and 0.3 gl/s) on a first-generation, dual-source PCD-CT. Polychromatic images (T3D) and virtual monoenergetic images were reconstructed in the range of 40 to 70 keV in 5-keV steps. Attenuation and noise were measured in the coronary arteries and background material and the contrast-to-noise ratio (CNR) were calculated. Attenuation of 350 HU and a CNR of the reference protocol at 70 keV were regarded as sufficient for simulation of diagnostic purposes. Vessel sharpness and noise power spectra were analyzed for the aforementioned reconstructions.The standard clinical contrast protocol (bolus with 100% contrast) yielded diagnostic coronary artery attenuation for all tested reconstructions (>398 HU). A 50% reduction in contrast media concentration demonstrated sufficient attenuation of the coronary arteries at 40 to 55 keV (>366 HU). Virtual monoenergetic image reconstructions of 40 to 45 and 40 keV allowed satisfactory attenuation of the coronary arteries for contrast concentrations of 40% and 30% of the original protocol. A reduction of contrast agent concentration to 20% of the initial concentration provided insufficient attenuation in the target vessels for all reconstructions. The highest CNR was found for virtual monoenergetic reconstructions at 40 keV for all contrast media injection protocols, yielding a sufficient CNR at a 50% reduction of contrast agent concentration.Using virtual monoenergetic image reconstructions at 40 keV on a dual-source PCD-CT system, contrast media concentration could be reduced by 50% to obtain diagnostic attenuation and objective image quality for coronary CT angiography in a dynamic vessel phantom. These initial feasibility study results have to be validated in clinical studies. read more
Citations
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Journal ArticleDOI
Ultra-high resolution photon-counting coronary CT angiography improves coronary stenosis quantification over a wide range of heart rates - A dynamic phantom study.
Emese Zsarnóczay,Nicola Fink,U. Joseph Schoepf,Jim O'Doherty,T. Allmendinger,Junia Hagenauer,Elias V Wolf,Joseph P. Griffith,Pál Maurovich-Horvat,Akos Varga-Szemes,Tilman Emrich +10 more
TL;DR: In this paper , the effect of using photon-counting detector (PCD)-CT with ultra-high resolution (UHR) on stenosis quantification accuracy and blooming artifacts from low to high heart rates in a dynamic motion phantom was investigated.
Journal ArticleDOI
First Experience With a Whole-Body Spectral Photon-Counting CT Clinical Prototype
TL;DR: Spectral photon-counting computed tomography (SPCCT) technology holds great promise for becoming the next generation of CT systems as discussed by the authors , which provides better spatial resolution, greater dose efficiency for ultra-low-dose and low-dose protocols, and tissue contrast superior to that of conventional CT.
Journal ArticleDOI
Photon Counting Detector CT-Based Virtual Noniodine Reconstruction Algorithm for In Vitro and In Vivo Coronary Artery Calcium Scoring: Impact of Virtual Monoenergetic and Quantum Iterative Reconstructions
Шаамирова Юлдузхон Кабильджановна,Maziah, CA. Astuti Darmayanti, Saprialman,Radiah Radiah,Marcello Iotti,Ioana Baiu,Rami Qanneta,Laura Rodríguez-Rodríguez,None Nurhayati,Joseph G. Gleeson,Jan Fairley,NMNH Division of Mammals +10 more
TL;DR: In this paper , the authors evaluated the impact of virtual noniodine reconstruction (VNI) and quantum iterative reconstruction (QIR) on the accuracy of coronary artery calcium scoring using a first-generation, clinical, photon counting detector computed tomography system.
Journal ArticleDOI
High-Pitch Multienergy Coronary CT Angiography in Dual-Source Photon-Counting Detector CT Scanner at Low Iodinated Contrast Dose
TL;DR: In this article , the authors evaluated the high-helical pitch, multi-energy (ME) scanning mode of a clinical dual-source photon-counting detector (PCD) computed tomography (CT) and the benefit of virtual monoenergetic images (VMIs) for low-contrast-dose coronary CT angiography.
Journal ArticleDOI
Technical Basics and Clinical Benefits of Photon-Counting CT
TL;DR: In this paper , the basic principles and potential clinical benefits of photon-counting detector CT (PCD-CT) are discussed. But the authors focus on recent literature that has grown rapidly since the commercial introduction of a clinically approved PCDCT.
References
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Journal ArticleDOI
2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes.
Juhani Knuuti,William Wijns,Antti Saraste,Davide Capodanno,Emanuele Barbato,Christian Funck-Brentano,Eva Prescott,Robert F. Storey,Christi Deaton,Thomas Cuisset,Stefan Agewall,Kenneth Dickstein,Thor Edvardsen,Javier Escaned,Bernard J. Gersh,Pavel Svitil,Martine Gilard,David Hasdai,Robert Hatala,Felix Mahfoud,Josep Masip,Claudio Muneretto,Marco Valgimigli,Stephan Achenbach,Jeroen J. Bax +24 more
TL;DR: In this article, the authors present guidelines for the management of patients with coronary artery disease (CAD), which is a pathological process characterized by atherosclerotic plaque accumulation in the epicardial arteries.
Journal ArticleDOI
Photon-counting CT: Technical Principles and Clinical Prospects.
TL;DR: The authors will explain the technical principles of photon-counting CT in nonmathematical terms for radiologists and clinicians to create opportunities for quantitative imaging relative to current CT technology.
Journal ArticleDOI
Soap-Bubble visualization and quantitative analysis of 3D coronary magnetic resonance angiograms
Alex Etienne,Alex Etienne,René M. Botnar,René M. Botnar,Arianne Van Muiswinkel,Peter Boesiger,Warren J. Manning,Matthias Stuber,Matthias Stuber +8 more
TL;DR: A software tool that facilitates visualization and objective, quantitative comparisons of coronary MRA data obtained with different scanning methods was developed and the first results obtained in healthy adults and in patients with coronary artery disease are presented.
Journal ArticleDOI
Post-contrast acute kidney injury - Part 1: Definition, clinical features, incidence, role of contrast medium and risk factors : Recommendations for updated ESUR Contrast Medium Safety Committee guidelines.
Aart J. van der Molen,Peter Reimer,Ilona A. Dekkers,Georg Bongartz,Marie-France Bellin,Michele Bertolotto,Olivier Clément,Gertraud Heinz-Peer,Fulvio Stacul,Judith A. W. Webb,Henrik S. Thomsen +10 more
TL;DR: PC-AKI is the preferred term for renal function deterioration after contrast medium, and the risk of AKI caused by intravascular contrast medium has been overstated.
Journal ArticleDOI
The Updated NICE Guidelines: Cardiac CT as the First-Line Test for Coronary Artery Disease.
TL;DR: Cardiac CT is recommended as the first-line test for the evaluation of stable coronary artery disease in chest pain pathways by NICE, and randomised controlled trials have demonstrated that cardiac CT improves diagnostic certainty when incorporated intochest pain pathways.