Journal ArticleDOI
Regulation of Inducible AmpC β‐Lactamase Expression Among Enterobacteriaceae
N. D. Hanson,C. C. Sanders +1 more
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This article is published in ChemInform.The article was published on 2000-02-08. It has received 161 citations till now. The article focuses on the topics: Enterobacteriaceae.read more
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Journal ArticleDOI
AmpC β-Lactamases
TL;DR: Overexpression confers resistance to broad-spectrum cephalosporins including cefotaxime, ceftazidime, and ceftriaxone and is a problem especially in infections due to Enterobacter aerogenes and Enterobacteria cloacae, where an isolate initially susceptible to these agents may become resistant upon therapy.
Journal ArticleDOI
Antibacterial-Resistant Pseudomonas aeruginosa: Clinical Impact and Complex Regulation of Chromosomally Encoded Resistance Mechanisms
TL;DR: This review highlights the clinical significance of chromosomally encoded AmpC cephalosporinase, the outer membrane porin OprD, and the multidrug efflux pumps, as well as the complex mechanisms/pathways by which P. aeruginosa regulates their expression.
Journal ArticleDOI
Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes.
TL;DR: They were initially reported in the second half of the 1980s, and their rate of dissemination among bacteria and in most parts of the world has increased dramatically since 1995, with the CTX-M β-lactamases being the most widespread enzymes.
Journal ArticleDOI
Detection of plasmid-mediated ampc beta-lactamase genes in clinical isolates by using multiplex pcr
TL;DR: A multiplex PCR technique was developed for identifying family-specific ampC genes responsible for AmpC β-lactamase expression in organisms with or without a chromosomal AmpCβ-l lactamase gene.
Journal ArticleDOI
Three Decades of β-Lactamase Inhibitors
TL;DR: In this paper, the authors review the catalytic mechanisms of each β-lactamase class and discuss approaches for circumventing β-latamase-mediated resistance, including properties and characteristics of mechanism-based inactivators.
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Journal Article
Regulation of inducible AmpC beta-lactamase expression among Enterobacteriaceae.
TL;DR: The intent of this review is to address the general mechanism involved in AmpC induction, and the genes and gene products required for the process of ampC induction are described.