Regulation of Repressor Expression in λ
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The product of this gene cro prevents expression of immunity and regulates the expression of those genes to the left of the immunity region in bacteriophage λ.Abstract:
A new gene in bacteriophage λ is described. The product of this gene cro prevents expression of immunity and regulates the expression of those genes to the left of the immunity region. cro- mutants have been isolated and characterized.read more
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Journal ArticleDOI
Dynamical behaviour of biological regulatory networks--I. Biological role of feedback loops and practical use of the concept of the loop-characteristic state.
TL;DR: The recent concept of the loop-characteristic state, defined as the logical state located at the level of the thresholds involved in the loop, together with its application, are presented and their applications are discussed.
Journal ArticleDOI
Switches in bacteriophage lambda development.
TL;DR: How a relatively simple phage like lambda employs a complex genetic network in decision-making processes, providing a challenge for theoretical modeling is discussed.
Book ChapterDOI
On the Relation Between the Logical Structure of Systems and Their Ability to Generate Multiple Steady States or Sustained Oscillations
TL;DR: For more complex systems, as far as one can tell, the presence of at least one negative loop in the logical structure appears as a necessary (but not sufficient) condition for a permanent periodic behaviour, and the absence of a positive loop is not a necessary condition for multiple steady states.
Journal ArticleDOI
lambda Repressor and cro--components of an efficient molecular switch.
Alexander D. Johnson,Anthony R. Poteete,Anthony R. Poteete,Gail Lauer,Robert T. Sauer,Gary K. Ackers,Mark Ptashne +6 more
TL;DR: In a lysogen, most genes of phage λ are repressed; in response to a transient induction signal, they are efficiently switched on.
Journal ArticleDOI
Cyclic adenosine 5'-monophosphate in Escherichia coli.
TL;DR: The role of cyclic AMP in regulation of gene expression and its possible role as a negative element in CRP structure are explained.