Journal ArticleDOI
Relation of Anterior Cruciate Ligament Tears to Potential Chronic Cardiovascular diseases
William P. Meehan,Marc G. Weisskopf,Supriya Krishnan,Caitlin M. McCracken,Ross Zafonte,Herman A. Taylor,Herman A. Taylor,Aaron L. Baggish,Alvaro Pascual-Leone,Lee M. Nadler,Frank E. Speizer,Frank E. Speizer +11 more
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TLDR
Enhanced screening for other risk factors for these conditions in patients who have torn their ACL might identify those who could most benefit from prevention strategies.Abstract:
We have enrolled a cohort of former National Football League players (n = 3,506) who played since 1960 to assess potential long term health consequences associated with participating in the sport Each participant has completed a self-administered questionnaire including reporting of physician-diagnosed health conditions One of the early assessments was to evaluate whether anterior cruciate ligament (ACL) tears were associated with later life co-morbidities, including cardiovascular effects We used Cox proportional hazards to estimate hazard ratios (HR) for joint replacement surgeries, myocardial infarction, sleep apnea, arthritis, dementia, and stroke by history of ACL tear during their professional career For additional outcomes without date of occurrence reported we used logistic regression to estimate odds ratios adjusted for potential confounding variables in all models After adjusting for covariates, former National Football League players who tore their ACL had approximately a twofold increase in muscular skeletal co-morbidities, including knee joint replacement and arthritis, compared with those without ACL tears In addition, those with a history of ACL tears also had more than a 50% increased risk of myocardial infarction (HR 152; 95% confidence interval 097 to 238) and a slight increase in sleep apnea (HR 115; 95% confidence interval 096 to 138) ACL tears sustained by athletes may increase the risk of co-morbidities beyond the musculoskeletal system As there are more than 100,000 ACL reconstructions annually in the United States, our findings could have widespread public health importance if these findings generalize to a population beyond professional football players In conclusion, enhanced screening for other risk factors for these conditions in patients who have torn their ACL might identify those who could most benefit from prevention strategiesread more
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Journal ArticleDOI
Mortality Among Professional American-Style Football Players and Professional American Baseball Players.
Vy T Nguyen,Ross Zafonte,Jarvis T. Chen,Kalé Z. Kponee-Shovein,Sabrina Paganoni,Alvaro Pascual-Leone,Frank E. Speizer,Frank E. Speizer,Aaron L. Baggish,Herman A. Taylor,Lee M. Nadler,Theodore K. Courtney,Ann Connor,Marc G. Weisskopf +13 more
TL;DR: It was found that NFL players had a higher rate of mortality than MLB players, which may be associated with aspects of playing in professional American-style football.
Journal ArticleDOI
The Football Players' Health Study at Harvard University: Design and objectives.
Ross Zafonte,Ross Zafonte,Alvaro Pascual-Leone,Alvaro Pascual-Leone,Aaron L. Baggish,Marc G. Weisskopf,Herman A. Taylor,Ann Connor,Ann Connor,Jillian Baker,Sarah Cohan,Chelsea Valdivia,Theodore K. Courtney,I. Glenn Cohen,Frank E. Speizer,Frank E. Speizer,Lee M. Nadler +16 more
TL;DR: The components of the FPHS studies undertaken and completed thus far, as well as those studies currently underway or planned for the near future are described.
Journal ArticleDOI
Self-Reported Cognitive Function and Mental Health Diagnoses among Former Professional American-Style Football Players
Franziska Plessow,Alvaro Pascual-Leone,Alvaro Pascual-Leone,Caitlin M. McCracken,Caitlin M. McCracken,Jillian Baker,Supriya Krishnan,Aaron L. Baggish,Ann Connor,Ann Connor,Theodore K. Courtney,Lee M. Nadler,Frank E. Speizer,Frank E. Speizer,Herman A. Taylor,Marc G. Weisskopf,Ross Zafonte,Ross Zafonte,William P. Meehan,William P. Meehan +19 more
TL;DR: Former players reporting daily cognitive problems were more likely to report memory loss and attention deficit(/hyperactivity) disorder and poorer general mental health, lower quality of life, less satisfaction with social activities and relationships, and more emotional problems.
Journal ArticleDOI
Defining Exposures in Professional Football: Professional American-Style Football Players as an Occupational Cohort.
Rachel Grashow,Andrea L. Roberts,Ross Zafonte,Ross Zafonte,Alvaro Pascual-Leone,Alvaro Pascual-Leone,Herman A. Taylor,Herman A. Taylor,Aaron L. Baggish,Lee M. Nadler,Theodore K. Courtney,Ann Connor,Ann Connor,Marc G. Weisskopf +13 more
TL;DR: The traditional occupational epidemiological approach to assessing exposure in a novel cohort is described and how this framework could be implemented in studies of professional football players is shown.
Journal ArticleDOI
Nationwide sports injury prevention strategies: A scoping review.
TL;DR: Mapping the strategies onto the TRIPP framework highlighted that only four (17%) of the 24 included strategies reported on the implementation context (TRIPP Stage 5), suggesting an important reporting gap.
References
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Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial
Robert S. Bresalier,Robert S. Sandler,Hui Quan,James A. Bolognese,Bettina Oxenius,Kevin J. Horgan,Christopher Lines,Robert H. Riddell,Dion Morton,Angel Lanas,Marvin A. Konstam,John A. Baron +11 more
TL;DR: Among patients with a history of colorectal adenomas, the use of rofecoxib was associated with an increased cardiovascular risk, and cardiovascular mortality was similar in the two groups.
Journal ArticleDOI
High prevalence of knee osteoarthritis, pain, and functional limitations in female soccer players twelve years after anterior cruciate ligament injury.
TL;DR: A very high prevalence of radiographic knee OA, pain, and functional limitations was observed in young women who sustained an ACL tear during soccer play 12 years earlier, constituting a strong rationale to direct increased efforts toward prevention and better treatment of knee injury.
Journal ArticleDOI
Agreement between self-report questionnaires and medical record data was substantial for diabetes, hypertension, myocardial infarction and stroke but not for heart failure
TL;DR: Questionnaire data are of greatest value in life-threatening, acute-onset diseases and chronic disorders requiring ongoing management and are more accurate in young women and better-educated subjects.
Journal ArticleDOI
Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis.
Sven Trelle,Stephan Reichenbach,Simon Wandel,Pius Hildebrand,Beatrice Tschannen,Peter M. Villiger,Matthias Egger,Peter Jüni +7 more
TL;DR: Although uncertainty remains, little evidence exists to suggest that any of the investigated drugs are safe in cardiovascular terms, and Naproxen seemed least harmful.
Journal ArticleDOI
High prevalence of osteoarthritis 14 years after an anterior cruciate ligament tear in male soccer players: a study of radiographic and patient relevant outcomes
TL;DR: A high prevalence of radiographic knee osteoarthritis was seen in male soccer players 14 years after an ACL disruption, and the patient relevant outcome was affected and did not differ between subjects with and without radiographic changes.