Relation of mitochondrial phospholipase A activity to mitochondrial swelling.
Moseley Waite,Moseley Waite,L.L.M. van Deenen,L.L.M. van Deenen,T.J.C. Ruigrok,T.J.C. Ruigrok,P.F. Elbers,P.F. Elbers +7 more
TLDR
The temperature dependence of spontaneous, fatty acid-induced, or CaCl(2)-induced swelling suggested that enzymatic activities are responsible for swelling, although swelling due to contaminating lysosomes cannot be excluded entirely.About:
This article is published in Journal of Lipid Research.The article was published on 1969-09-01 and is currently open access. It has received 59 citations till now. The article focuses on the topics: Swelling & Fatty acid.read more
Citations
More filters
Journal ArticleDOI
Mechanisms by which mitochondria transport calcium.
Thomas E. Gunter,D. R. Pfeiffer +1 more
TL;DR: It has been suggested that the permeability transition and its reversal may also function as a mitochondrial Ca2+ efflux mechanism under some conditions.
Journal ArticleDOI
Relationship between configuration, function, and permeability in calcium-treated mitochondria.
TL;DR: The results of this work indicate that mitochondria have a built-in mechanism which responds to low levels of calcium, phosphate, and fatty acids, resulting in simultaneous changes, including increased permeability, inducation of ATPase, uncoupling of oxidative phosphorylation, and loss of respiratory control.
Journal ArticleDOI
FUNCTIONAL and STRUCTURAL ASPECTS OF BIOLOGICAL MEMBRANES: A SUGGESTED STRUCTURAL ROLE FOR VITAMIN E IN THE CONTROL OF MEMBRANE PERMEABILITY and STABILITY
TL;DR: It is proposed that uncontrolled changes in membrane permeability and stability may occur in the absence of vitamin E, and hence that a deficiency of this vitamin may lead to a failure of compartmentalization by biological membranes.
Journal ArticleDOI
The biochemical modes of action of vitamin e and selenium: A hypothesis.
A.T. Diplock,Jack A. Lucy +1 more
TL;DR: Recent experimental work on rat liver is discussed which is considered to indicate that a primary function of vitamin E in vivo may be to inhibit the oxidation of selenide‐containing proteins present in mitochondria and in smooth endoplasmic reticulum.
References
More filters
Journal ArticleDOI
Enzymatic properties of the inner and outer membranes of rat liver mitochondria
TL;DR: The inner membrane-matrix fraction retained a high degree of morphological and biochemical integrity and exhibited a high respiratory rate and respiratory control when assayed in a sucrose-mannitol medium containing EDTA.
Journal ArticleDOI
DIFFERENCES IN ENZYME CONTENT OF AZUROPHIL AND SPECIFIC GRANULES OF POLYMORPHONUCLEAR LEUKOCYTES : I. Histochemical Staining of Bone Marrow Smears
TL;DR: Findings confirm and extend those obtained previously, indicating that azurophil granules correspond to lysosomes whereas specific granules represent a different secretory product.
Journal ArticleDOI
Hydrolysis of phospholipids and glycerides by rat-liver preparations
Moseley Waite,L.L.M. Van Deenen +1 more
TL;DR: Rat-liver homogenates were found to hydrolyze phospholipids, giving rise to both the 1-acyil and 2-acyl lysoderivatives, and studies using inhibitors and heat inactivation show that the phospholIPase A2 requires metal ions, that the lipase is sensitive to p-chloromercuribenzoate and that the lysophospholipase(s) are sensitive to deoxycholate and heating.
Journal ArticleDOI
An endogenous uncoupling and swelling agent in liver mitochondria and its enzymic formation.
TL;DR: The agent, here designated as U factor, which is heat-stable in nature and readily extracted from mitochondrial fractions with isooctane and other solvents, has been found to uncouple phosphorylation, release respiration from control by adenosine diphosphate, and cause the swelling of mitochondria.
Journal ArticleDOI
Some calculations on the turbidity of mitochondria and bacteria.
TL;DR: It is found that for osmotic swelling of spheroplasts or mitrochondria, the absorbancy varies nearly inversely with the volume, and for variations in size at constant concentration, the absorption varies directly as the four-thirds power of the volume of the particle.