Journal ArticleDOI
Relation of volume history of lungs to respiratory mechanics in anesthetized dogs
Jere Mead,Clarence R. Collier +1 more
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When anesthetized dogs were allowed to breathe spontaneously or were paralyzed and ventilated in the resting tidal range by means of a pump, pulmonary compliance fell progressively.Abstract:
When anesthetized dogs were allowed to breathe spontaneously or were paralyzed and ventilated in the resting tidal range by means of a pump, pulmonary compliance fell progressively. These changes w...read more
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Journal ArticleDOI
Impaired oxygenation in surgical patients during general anesthesia with controlled ventilation. a concept of atelectasis.
TL;DR: If the pattern of ventilation, by itself, may influence oxygenation during anesthesia and surgery, and the hypothesis that progressive pulmona...
Journal ArticleDOI
Effects of Recruiting Maneuvers in Patients with Acute Respiratory Distress Syndrome Ventilated with Protective Ventilatory Strategy
Salvatore Grasso,Luciana Mascia,Monica Del Turco,Paolo Malacarne,Francesco Giunta,Laurent Brochard,Arthur S. Slutsky,V. Marco Ranieri +7 more
TL;DR: Application of recruiting maneuvers improves oxygenation only in patients with early ARDS who do not have impairment of chest wall mechanics and with a large potential for recruitment, as indicated by low values of EstL.
Journal ArticleDOI
Airway smooth muscle, tidal stretches, and dynamically determined contractile states.
Jeffrey J. Fredberg,David S. Inouye,Brett Miller,Madhavi Nathan,Samah Jafari,Soufia Helioui Raboudi,James P. Butler,Stephanie A. Shore +7 more
TL;DR: It is concluded that the interactions of myosin with actin are at every instant tending toward those that would prevail in the isometric steady state, but tidal changes of muscle length cause an excess in the rate of detachment.
Journal ArticleDOI
Advances in Mechanical Ventilation
TL;DR: The basic principles of mechanical ventilation are reviewed, which were reviewed in the Journal in 1994, and recent advances are discussed.
Journal ArticleDOI
Ventilation with end-expiratory pressure in acute lung disease
TL;DR: The most probable explanation for the effect of PEEP on P(aO2) and compliance is recruitment of gas exchange airspaces and prevention of terminal airway closure.