Relationship Between Antidepressant Medication Treatment and Suicide in Adolescents
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TLDR
An inverse relationship between regional change in use of antidepressants and suicide raises the possibility of a role for using antidepressant treatment in youth suicide prevention efforts, especially for males, older adolescents, and adolescents who reside in lower-income regions.Abstract:
Context A decade of increasing antidepressant medication treatment for adolescents and corresponding declines in suicide rates raise the possibility that antidepressants have helped prevent youth suicide. Objective To evaluate the relationship between regional changes in antidepressant medication treatment and suicide in adolescents from 1990 to 2000. Design Analysis of prescription data from the nation's largest pharmacy benefit management organization, national suicide mortality files, regional sociodemographic data from the 1990 and 2000 US Census, and regional data on physicians per capita. Participants Youth aged 10 to 19 years who filled a prescription for antidepressant medication and same-aged completed suicides from 588 three-digit ZIP code regions in the United States. Main Outcome Measures The relationship between regional change in antidepressant medication treatment and suicide rate stratified by sex, age group, regional median income, and regional racial composition. Results There was a significant adjusted negative relationship between regional change in antidepressant medication treatment and suicide during the study period. A 1% increase in adolescent use of antidepressants was associated with a decrease of 0.23 suicide per 100 000 adolescents per year (β= −.023, t = −5.14, P t =−3.81, P t = −3.43, P t = −3.73, P Conclusions An inverse relationship between regional change in use of antidepressants and suicide raises the possibility of a role for using antidepressant treatment in youth suicide prevention efforts, especially for males, older adolescents, and adolescents who reside in lower-income regions.read more
Citations
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Journal ArticleDOI
Suicide prevention strategies: a systematic review.
J. John Mann,Alan Apter,José Manoel Bertolote,Annette L. Beautrais,Dianne Currier,Ann Pollinger Haas,Ulrich Hegerl,Jouko Lönnqvist,Kevin M. Malone,Andrej Marusic,Lars Mehlum,George C Patton,Michael R. Phillips,Wolfgang Rutz,Zoltán Rihmer,Armin Schmidtke,David Shaffer,Morton M. Silverman,Yoshitomo Takahashi,Airi Värnik,Danuta Wasserman,Paul S. F. Yip,Herbert Hendin +22 more
TL;DR: Physician education in depression recognition and treatment and restricting access to lethal methods reduce suicide rates, and other interventions need more evidence of efficacy.
PRACTICE GUIDELINE FOR THE Treatment of Patients With Major Depressive Disorder
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Adolescent suicide and suicidal behavior
TL;DR: Clinical and public health approaches to the reduction in youth suicide and recommendations for further research will be discussed.
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Suicidality in pediatric patients treated with antidepressant drugs.
TL;DR: Use of antidepressant drugs in pediatric patients is associated with a modestly increased risk of suicidality, and a meta-analysis was conducted to obtain overall suicidity risk estimates.
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Practice Parameter for the Assessment and Treatment of Children and Adolescents With Depressive Disorders
Boris Birmaher,David A. Brent,William Bernet,Oscar G. Bukstein,Heather J. Walter,R. Scott Benson,Allan K. Chrisman,Tiffany Farchione,Laurence L. Greenhill,John D. Hamilton,Helene Keable,Ulrich Schoettle,Saundra Stock,Kristin Kroeger Ptakowski,Jennifer Medicus,Amy Cheung,Greg Clarke,Graham J. Emslie,Philip Hazell,Stan Kutcher,Kelly Posner,Joseph M. Rey,Karen Dineen Wagner,Elizabeth B. Weller +23 more
TL;DR: This practice parameter describes the epidemiology, clinical picture, differential diagnosis, course, risk factors, and pharmacological and psychotherapy treatments of children and adolescents with major depressive or dysthymic disorders.
References
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