Journal ArticleDOI
Relationship Between Resistance to Insulin-Mediated Glucose Uptake, Urinary Uric Acid Clearance, and Plasma Uric Acid Concentration
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TLDR
Urinary uric acid clearance appears to decrease in proportion to increases in insulin resistance in normal volunteers, leading to an increase in serum uric Acid concentration, which appears to be exerted at the level of the kidney.Abstract:
Objective. —To define the relationship, if any, between insulin-mediated glucose disposal and serum uric acid. Design. —Cross-sectional study of healthy volunteers. Setting.— General Clinical Research Center, Stanford (Calif) University Medical Center. Participants. —Thirty-six presumably healthy individuals, nondiabetic, without a history of gout. Measurements. —Obesity (overall and regional), plasma glucose and insulin responses to a 75-g oral glucose load, fasting uric acid concentrations, plasma triglyceride and high-density lipoprotein—cholesterol concentrations, systolic and diastolic blood pressure, insulin-mediated glucose disposal, and urinary uric acid clearance. Results. —Magnitude of insulin resistance and serum uric acid concentration were significantly related ( r =.69; P r =.57; P r = -.49; P r = -.61; P Conclusions. —Urinary uric acid clearance appears to decrease in proportion to increases in insulin resistance in normal volunteers, leading to an increase in serum uric acid concentration. Thus, it appears that modulation of serum uric concentration by insulin resistance is exerted at the level of the kidney. ( JAMA . 1991;266:3008-3011)read more
Citations
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The metabolic syndrome
TL;DR: The pathophysiology seems to be largely attributable to insulin resistance with excessive flux of fatty acids implicated, and a proinflammatory state probably contributes to the metabolic syndrome.
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The Metabolic Syndrome
Marc-Andre Cornier,Dana Dabelea,Teri L. Hernandez,Rachel C. Lindstrom,Amy J. Steig,Nicole R. Stob,Rachael E. Van Pelt,Hong Wang,Robert H. Eckel +8 more
TL;DR: The "metabolic syndrome" is a clustering of components that reflect overnutrition, sedentary lifestyles, and resultant excess adiposity that is associated with an approximate doubling of cardiovascular disease risk and a 5-fold increased risk for incident type 2 diabetes mellitus.
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Serum Uric Acid and Cardiovascular Mortality: The NHANES I Epidemiologic Follow-up Study, 1971-1992
Jing Fang,Michael H. Alderman +1 more
TL;DR: Increased serum uric acid levels had a positive relationship to cardiovascular mortality in men and women and in black and white persons and stratifying by cardiovascular risk status, diuretic use, and menopausal status confirmed this relationship.
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The Metabolic Syndrome
TL;DR: The National Cholesterol Education Program’s Adult Treatment Panel III (ATP III) report added the metabolic syndrome, a multidimensional risk factor for cardiovascular disease (CVD), as a coequal partner of elevated low-density lipoprotein (LDL) cholesterol for risk-reduction therapies.
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American College of Endocrinology position statement on the insulin resistance syndrome.
Daniel Einhorn,Gerald M. Reaven,Rhoda H. Cobin,Earl S. Ford,Om P. Ganda,Yehuda Handelsman,Richard Hellman,Paul S. Jellinger,David M. Kendall,Ronald M Krauss,Naomi D. Neufeld,Steven M. Petak,Helena W. Rodbard,John A. Seibel,Donald A. Smith,Peter W. F. Wilson +15 more
References
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Journal ArticleDOI
Role of Insulin Resistance in Human Disease
TL;DR: The possibility is raised that resistance to insulin-stimulated glucose uptake and hyperinsulinemia are involved in the etiology and clinical course of three major related diseases— NIDDM, hypertension, and CAD.
Book
The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Immunoassay of insulin with insulin-antibody precipitate.
C.N. Hales,P.J. Randle +1 more
Journal ArticleDOI
The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man.
TL;DR: The effect of insulin on CH2O suggests that insulin's effect on sodium excretion is due to enhancement of sodium reabsorption in the diluting segment of the distal nephron, and a reduction in UNaV associated with insulin administration is demonstrated.