Patent
Remyelination of neurons using multipotent neural stem cell progeny
Reads0
Chats0
TLDR
In this paper, the authors presented methods for producing myelin forming cells from multipotent self-renewing central nervous system neural stem cells as well as methods of using one or more cells from a multipotent SRS neural stem cell population to form patches of myelin.Abstract:
The invention provides methods for producing myelin forming cells from multipotent self-renewing central nervous system neural stem cells as well as methods of using one or more cells from a multipotent self-renewing central nervous system neural stem cell population to form patches of myelin. Also provided are cell culture systems for forming patches of myelin and methods of treating demyelination diseases in a mammal.read more
Citations
More filters
Patent
Multipotent stem cells and uses thereof
TL;DR: In this paper, a quiescent stem cell having the capacity to differentiate into ectoderm, mesoderm and endoderm was provided, which does not express cell surface markers including MHC class I, mHC class II, CD44, CD45, CD13, CD34, CD49c, CD73, CD105 and CD90.
Patent
Target populations of oligodendrocyte precursor cells and methods of making and using same
Alexandra Capela,Nobuko Uchida +1 more
TL;DR: In this paper, the target OPCs may be expanded and optionally subjected to conditions to induce their differentiation into oligodendrocytes and their progeny are useful for the treatment of disease associated with demyelination of central nervous system axons.
Patent
Methods for obtaining adult human olfactory progenitor cells
TL;DR: An isolated human olfactory stem cell can be prepared by culturing human tissue from Olfactory neuroepithelium to form neurospheres as discussed by the authors, which can then be used as a stem cell.
Patent
Methods of treating epilepsy using neural stem cells that express nanog, SSEA-4, OCT-4, MIR-34B, MIR-34C and MIR-592
TL;DR: In this article, non-epileptic and epileptic neural stem cells and cell cultures were used to diagnose or prognosing an epilepsy or epilepsy-related disorder, and a method of treating an epilepsy and epilepsy related disorder.
Patent
Neural cell preparations and methods of making and using them
TL;DR: In this article, the authors describe methods for producing neural cells, in particular neural cell preparations comprising oligodendrocytes, pharmaceutical compositions comprising the neural cells or preparations, and the use of the neural cell, preparations and compositions in research or commercial applications.
References
More filters
Book
Culture of Animal Cells
TL;DR: Biology of Cultured Cells, Design and Layout, and Organotypic Culture: Problems Solving.
Journal ArticleDOI
Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
Brent A. Reynolds,Samuel Weiss +1 more
TL;DR: Cells of the adult mouse striatum have the capacity to divide and differentiate into neurons and astrocytes.
Journal ArticleDOI
CNS stem cells express a new class of intermediate filament protein.
TL;DR: The predicted amino acid sequence of the nestin gene product shows that nestin defines a distinct sixth class of intermediate filament protein, extending a model in which transitions in intermediate filament gene expression reflect major steps in the pathway of neural differentiation.
Journal ArticleDOI
GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
TL;DR: In embryonic midbrain cultures, recombinant human GDNF promoted the survival and morphological differentiation of dopaminergic neurons and increased their high-affinity dopamine uptake and did not increase total neuron or astrocyte numbers or transmitter uptake.
Journal ArticleDOI
A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium
TL;DR: It is suggested that fibrous astrocytes and oligodendrocyte develop from a common progenitor cell and provide a striking example of developmental plasticity and environmental influence in the differentiation of CNS glial cells.