Responses and adverse effects of carboplatin-based chemotherapy for pediatric intracranial germ cell tumors.
Suntae Ji,Hee Won Chueh,Ju Youn Kim,Su Jin Lim,Eun Joo Cho,Soo Hyun Lee,Keon Hee Yoo,Ki Woong Sung,Hong Hoe Koo +8 more
TLDR
The current carboplatin-based chemotherapy protocol is safe and effective for the treatment of pediatric patients with IC-GCTs and it is concluded that no lethal hematological complications were associated with this treatment.Abstract:
Purpose
Cisplatin-based chemotherapy has been commonly used for the treatment of intracranial germ cell tumors (IC-GCTs). However, this treatment exhibits some adverse effects such as renal problems and hearing difficulty. Carboplatin-based chemotherapy was administered to pediatric patients with IC-GCTs from August 2004 at the Samsung Medical Center. In this study, we assessed the responses and adverse effects of carboplatin-based chemotherapy in pediatric IC-GCTs patients according to the risk group, and compared the results with those of the previous cisplatin-based chemotherapy.read more
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Recent Advances in Platinum (IV) Complex-Based Delivery Systems to Improve Platinum (II) Anticancer Therapy
TL;DR: Recent advances in Pt (IV) complexes in combination with nanocarriers are highlighted, addressing the shortcomings of Pt ( IV) complexes, such as their instability in blood and irreversibly binding to plasma proteins and nonspecific distribution, and taking advantage of passive and active targeting effect to improve Pt (II) anticancer therapy.
Journal ArticleDOI
Pharmacokinetics, Tissue Distribution, and Plasma Protein Binding Study of Platinum Originating from Dicycloplatin, a Novel Antitumor Supramolecule, in Rats and Dogs by ICP-MS
Di Zhao,Yongjie Zhang,Chunxiang Xu,Can Dong,Hui Lin,Lingli Zhang,Cuiyun Li,Shuangxia Ren,Xin Wang,Shuoye Yang,Deen Han,Xijing Chen +11 more
TL;DR: Investigating the pharmacokinetic characteristics including plasma kinetics, tissue distribution, and plasma protein binding of platinum originating from dicycloplatin in rats and dogs in detail for the first time by ICP-MS showed that plasma concentrations of platinum began to decrease rapidly initially but decline slowly with a long terminal phase.
Journal ArticleDOI
Medulloblastoma/Primitive neuroectodermal tumor and germ cell tumors: the uncommon but potentially curable primary brain tumors.
TL;DR: An overview of medulloblastomas, central nervous system primitive neuroectodermal tumors, and germ cell tumors for the practicing oncologist is presented.
Journal ArticleDOI
Carboplatin-based regimen in pediatric intracranial germ-cell tumors (IC-GCTs): effectiveness and ototoxicity.
Rasin Worawongsakul,Nongnuch Sirachainan,Apimid Rojanawatsirivej,Atthaporn Boongird,Arunee Singhsnaeh,Thiti Swangsilpa,Mantana Dhanachai,Putipun Puataweepong,Rawee Ruangkanchanasetr,Samart Pakakasama,Usanarat Anurathapan,Duantida Songdej,Pongpak Pongphitcha,Chaiyos Khongkhatithum,Ake Hansasuta,Nintita Sripaiboonkij Thokanit,Apasri Lusawat,Sarunya Yuthagovit,Samasuk Thammachantha,Danupon Muangruk,Suradej Hongeng +20 more
TL;DR: Induction chemotherapy with carboplatin-based regimens was associated with excellent survival rates and low ototoxicity in patients with IC-GCT, and Radiotherapy should be given to all patients with a minimal volume equivalent to whole-ventricular radiotherapy, during which doses of lower than 40 Gy can be effectively used.
References
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Jörg T. Hartmann,Hans-Peter Lipp +1 more
TL;DR: Compared to cisplatin, carboplatin has inferior efficacy in germ-cell tumour, head and neck cancer and bladder and oesophageal carcinoma, whereas both drugs seem to have comparable efficacy in advanced non-small cell and small cell lung cancer as well as ovarian cancer.
Journal ArticleDOI
Intracranial Germ Cell Tumors
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