Journal ArticleDOI
Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity.
TLDR
Significant evidence is outlined from multiidisciplinary approaches for amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity and protection against these oxidative processes and cell death by free radical scavengers and the strong evidence supporting the notion that the single methionine residue of amyloids beta- peptide is vital to the oxidative Stress and neurotoxicological properties of this peptide.About:
This article is published in Journal of Structural Biology.The article was published on 2000-06-01. It has received 719 citations till now. The article focuses on the topics: Biochemistry of Alzheimer's disease & Senile plaques.read more
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Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution
TL;DR: The 'new view' of these diseases suggests that other degenerative conditions could have similar underlying origins to those of the amyloidoses, and suggests some intriguing new factors that could be of great significance in the evolution of biological molecules and the mechanisms that regulate their behaviour.
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Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Aβ42 fibrils
TL;DR: The hypothesis that Aβ42 fibrils can accelerate NFT formation in vivo is supported, and NFTs that contained tau phosphorylated at serine 212/threonine 214 and serine 422 were identified.
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Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)
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The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse
Giselle P. Lim,Teresa Chu,Fusheng Yang,Walter Beech,Sally A. Frautschy,Sally A. Frautschy,Greg M. Cole,Greg M. Cole +7 more
TL;DR: Low and high doses of curcumin significantly lowered oxidized proteins and interleukin-1β, a proinflammatory cytokine elevated in the brains of these mice, and shows promise for the prevention of Alzheimer's disease.
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Antioxidant Activity of Proteins and Peptides
TL;DR: While proteins and peptides have excellent potential as food antioxidants, issues such as allergenicity and bitter off-flavors as well as their ability to alter food texture and color need to be addressed.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
Elizabeth H. Corder,Ann M. Saunders,Warren J. Strittmatter,Donald E. Schmechel,P. C. Gaskell,Gary W. Small,A. D. Roses,Jonathan L. Haines,Margaret A. Pericak-Vance +8 more
TL;DR: The APOE-epsilon 4 allele is associated with the common late onset familial and sporadic forms of Alzheimer9s disease (AD) in 42 families with late onset AD.
Journal ArticleDOI
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.
TL;DR: This review provides a comprehensive summary on the chemical properties of 4-hydroxyalkenals and malonaldehyde, the mechanisms of their formation and their occurrence in biological systems and methods for their determination, as well as the many types of biological activities described so far.
Book
Critical Stability Constants
TL;DR: Erratum to: Aminocarboxylic Acids to: Iminodiacetic Acid Derivatives to: Peptides to: Aliphatic Amines to: Protonation Values for other Ligands.
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Alzheimer's disease: the amyloid cascade hypothesis
John Hardy,Gerald A. Higgins +1 more
TL;DR: An extensive catalog of genes that act in a migrating cell is provided, unique molecular functions involved in nematode cell migration are identified, and similar functions in humans are suggested.