Risk and outcomes of aortic valve endocarditis among patients with bicuspid and tricuspid aortic valves
Kiyota Y,Alessandro Della Corte,Vanessa Montiero Vieira,Karam M. Habchi,Chuan-Chin Huang,Ester Della Ratta,Thoralf M. Sundt,Prem Shekar,Jochen D. Muehlschlegel,Simon C. Body +9 more
- Vol. 4, Iss: 1
TLDR
Patients with BAV are at markedly increased risk of IE and aortic root abscess than patients with TAV, which indicates they may be a candidate group for long-term trials of antibiotic prophylaxis of IE.Abstract:
Objective Patients with structural abnormalities of cardiac valves, including bicuspid aortic valve (BAV), are said to be at higher risk of infective endocarditis (IE) We sought to determine the risk of IE of the BAV compared with the tricuspid aortic valve (TAV) and to determine the risk of aortic valve replacement and mortality after IE Methods From medical records of two US and one Italian hospitals, patients with their first episode of IE of any native valve were identified In the US cohort 42 patients with BAV and 393 patients with TAV with IE occurring between 1 January 2000 and 30 June 2014 were identified In the Italian cohort 48 patients with BAV and 341 patients with TAV with IE underwent valve replacement surgery between 1 January 2000 and1 November 2015 The risk of IE for BAV and TAV and subsequent outcomes were determined after matching to patients without IE Results After adjustment for risk factors, the risk of IE in the US cohort was 231 (95% CI 81 to 100, p Conclusions Patients with BAV are at markedly increased risk of IE and aortic root abscess than patients with TAV Increased risk of IE in patients with BAV indicates they may be a candidate group for long-term trials of antibiotic prophylaxis of IEread more
Citations
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Journal ArticleDOI
Pathogenic Mechanisms of Bicuspid Aortic Valve Aortopathy.
TL;DR: Evidence is provided that aortic root AAD has a stronger genetic etiology, sometimes related to identified common non-coding fibrillin-1 (FBN1) variants and other aortsic wall protein variants in patients with BAV, and a stronger hemodynamic influence, but with pathology still based on a functional deficit of the aortics media, of genetic or epigenetic etiology.
Journal ArticleDOI
Incidence of Infective Endocarditis in Patients with Bicuspid Aortic Valves in the Community
Journal ArticleDOI
Utilizing wall shear stress as a clinical biomarker for bicuspid valve-associated aortopathy.
TL;DR: Find and validating noninvasive hemodynamic biomarkers of aortic risk to assist in the management of BAV patients is of clinical importance.
Journal ArticleDOI
Infective endocarditis in intravenous drug users.
TL;DR: This work aims to provide a comprehensive review of injection IVDU epidemiology, mechanism, medical and surgical treatment, ethical dilemmas involved in the treatment of this high-risk population, and future directions in the management of this lethal disease.
References
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Comorbidity measures for use with administrative data.
TL;DR: The present method addresses some of the limitations of previous measures and produces an expanded set of comorbidities that easily is applied without further refinement to administrative data for a wide range of diseases.
Journal ArticleDOI
Proposed Modifications to the Duke Criteria for the Diagnosis of Infective Endocarditis
Jennifer S. Li,Daniel J. Sexton,Nathan Mick,Richard E. Nettles,Vance G. Fowler,Thomas J. Ryan,Thomas M. Bashore,G. R. Corey +7 more
TL;DR: Modifications of the Duke criteria for the diagnosis of infective endocarditis are proposed, including that positive Q-fever serology should be changed to a major criterion and the minor criterion "echocardiogram consistent with IE but not meeting major criterion" should be eliminated.
Journal ArticleDOI
Prevention of Infective Endocarditis Guidelines From the American Heart Association: A Guideline From the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group
Walter R. Wilson,Kathryn A. Taubert,Michael H. Gewitz,Peter B. Lockhart,Larry M. Baddour,Matthew E. Levison,Ann F. Bolger,Christopher H. Cabell,Masato Takahashi,Robert S. Baltimore,Jane W. Newburger,Brian L. Strom,Lloyd Y. Tani,Michael A. Gerber,Robert O. Bonow,Thomas J. Pallasch,Stanford T. Shulman,Anne H. Rowley,Jane C. Burns,Patricia Ferrieri,Timothy J. Gardner,David Goff,David T. Durack +22 more
TL;DR: In this article, the authors updated the recommendations by the American Heart Association (AHA) for the prevention of infective endocarditis that were last published in 1997, and the purpose of this statement is to update the recommendations.
Journal ArticleDOI
Clinical Presentation, Etiology, and Outcome of Infective Endocarditis in the 21st Century: The International Collaboration on Endocarditis-Prospective Cohort Study
David R. Murdoch,G. Ralph Corey,Bruno Hoen,José M. Miró,Vance G. Fowler,Arnold S. Bayer,Adolf W. Karchmer,Lars Olaison,Paul A. Pappas,Philippe Moreillon,Stephen T. Chambers,Vivian H. Chu,Vicenç Falcó,David Holland,Philip Jones,John L Klein,Nigel Raymond,Kerry Read,Marie Francoise Tripodi,Riccardo Utili,Andrew Wang,Christopher W. Woods,Christopher H. Cabell +22 more
TL;DR: In the early 21st century, IE is more often an acute disease, characterized by a high rate of S aureus infection, and Mortality remains relatively high.
Journal ArticleDOI
Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group.
Walter R. Wilson,Kathryn A. Taubert,Michael H. Gewitz,Peter B. Lockhart,Larry M. Baddour,Matthew E. Levison,Ann F. Bolger,Christopher H. Cabell,Masato Takahashi,Robert S. Baltimore,Jane W. Newburger,Brian L. Strom,Lloyd Y. Tani,Michael A. Gerber,Robert O. Bonow,Thomas J. Pallasch,Stanford T. Shulman,Anne H. Rowley,Jane C. Burns,Patricia Ferrieri,Timothy J. Gardner,David Goff,David T. Durack +22 more
TL;DR: The committee concluded that only an extremely small number of cases of IE might be prevented by antibiotic prophylaxis for dental procedures even if suchProphylactic therapy were 100 percent effective.
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Isabel Zegri-Reiriz,Arístides de Alarcón,Patricia Muñoz,Manuel Martínez Sellés,Víctor González-Ramallo,José M. Miró,C. Falces,Claudia Gonzalez Rico,Xabier Kortajarena Urkola,José Antonio Lepe,Regino Rodriguez Alvarez,Jose Maria Reguera Iglesias,Enrique Navas,Fernando Dominguez,Pablo García-Pavía +14 more