Risk factors for polymyxin B-associated acute kidney injury.
Kang Han Chang,Haibo Wang,Jianping Zhao,Xianghong Yang,B.H. Wu,Wenkui Sun,Man Huang,Zhenshun Cheng,Hong Chen,Yuanlin Song,Ping Chen,Xiangqian Chen,Xin Gan,Wanli Ma,Lihua Xing,Limin Wang,B. Cao +16 more
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TLDR
In this article , a multicenter, retrospective cohort study included patients from 14 Chinese teaching hospitals who received polymyxin B therapy. And a multivariate logistic regression model was used to identify independent risk factors for AKI.About:
This article is published in International Journal of Infectious Diseases.The article was published on 2022-01-01 and is currently open access. It has received 6 citations till now. The article focuses on the topics: Medicine & Medicine.read more
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Polymyxin B-Based Regimens for Patients Infected with Carbapenem-Resistant Gram-Negative Bacteria: Clinical and Microbiological Efficacy, Mortality, and Safety
TL;DR: PMB is a relatively safe and effective antibiotic drug for treatment of critically ill patients with CR-GNB infection; however, PMB use should be subject to guidelines recommendations for early administration, loading administration, and adequate administration, which could help to improve the clinical efficacy, microbiological efficacy, and mortality.
Journal ArticleDOI
Polymyxin B-Based Regimens for Patients Infected with Carbapenem-Resistant Gram-Negative Bacteria: Clinical and Microbiological Efficacy, Mortality, and Safety
TL;DR: In this article , the efficacy and safety of polymyxin B (PMB)-based regimens and factors influencing their effectiveness were explored in patients with carbapenem-resistant Gram-negative bacteria (CR-GNB) infection.
Journal ArticleDOI
Correlation between the drug concentration of polymyxin B and polymyxin B‐associated acute kidney injury in critically ill patients: A prospective study
TL;DR: The incidence of PB‐AKI is high and related to the loading dose of PB, which could be predicted when the estimated AUC0–24 of PB was greater than 97.72 mg·h/L.
Journal ArticleDOI
Clinical efficacy and nephrotoxicity of intravenous colistin sulfate in the treatment of carbapenem-resistant gram-negative bacterial infections: a retrospective cohort study
Jun Jin,Jinhui Zhu,Zheng H. Zhu,Won Yong Kim,James O'Rourke,Zong-Han Lin,Min-Hsin Yang ； Yu-Hui Huang ； Sung-Lang Chen +6 more
TL;DR: Wang et al. as discussed by the authors evaluated the effectiveness and nephrotoxicity of intravenous colistin sulfate in the treatment of carbapenem-resistant gram-negative bacteria (CR-GNB) infections.
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Prevalence of polymyxin-induced nephrotoxicity and its predictors in critically ill adult patients: A meta-analysis
TL;DR: In this article , the authors conducted a systematic review and meta-analysis of the prevalence and potential predictors of polymyxin-induced nephrotoxicity in adult intensive care unit (ICU) patients.
References
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A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation☆
TL;DR: The method of classifying comorbidity provides a simple, readily applicable and valid method of estimating risk of death fromComorbid disease for use in longitudinal studies and further work in larger populations is still required to refine the approach.
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The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine.
Jean Louis Vincent,R. Moreno,Jukka Takala,Sheila Willatts,A. de Mendonça,Hajo A. Bruining,C. K. Reinhart,P. M. Suter,L. G. Thijs +8 more
TL;DR: The ESICM developed a so-called sepsis-related organ failure assessment (SOFA) score to describe quantitatively and as objectively as possible the degree of organ dysfunction/failure over time in groups of patients or even in individual patients.
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KDIGO clinical practice guidelines for acute kidney injury.
TL;DR: The guidelines focused on 4 key domains: (1) AKI definition, (2) prevention and treatment of AKI, (3) contrastinduced AKI (CI-AKI) and (4) dialysis interventions for the treatment ofAKI.
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Acute Kidney Injury, Mortality, Length of Stay, and Costs in Hospitalized Patients
TL;DR: Modest changes in SCr were significantly associated with mortality, LOS, and costs, even after adjustment for age, gender, admission International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis, severity of illness (diagnosis-related group weight), and chronic kidney disease.
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Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis.
TL;DR: A systematic review of cohort studies evaluating long-term renal outcomes and non-renal outcomes in patients with and without AKI identifies AKI as an independent risk factor for CKD, ESRD, death, and other important non- renewable outcomes.