Risk of New Vertebral Fracture in the Year Following a Fracture
Robert S. Lindsay,Stuart L. Silverman,Cyrus Cooper,David A. Hanley,I P Barton,Susan B. Broy,Angelo A. Licata,Laurent Benhamou,Piet Geusens,Kirsten Flowers,Hilmar Stracke,Ego Seeman +11 more
TLDR
The data indicate that women who develop a vertebral fracture are at substantial risk for additional fracture within the next year, and the presence of prevalent vertebral fractures increases this risk.Abstract:
ContextVertebral fractures significantly increase lifetime risk of future fractures,
but risk of further vertebral fractures in the period immediately following
a vertebral fracture has not been evaluated.ObjectiveTo determine the incidence of further vertebral fracture in the year
following a vertebral fracture.Design and SettingAnalysis of data from 4 large 3-year osteoporosis treatment trials conducted
at 373 study centers in North America, Europe, Australia, and New Zealand
from November 1993 to April 1998.SubjectsPostmenopausal women who had been randomized to a placebo group and
for whom vertebral fracture status was known at entry (n = 2725).Main Outcome MeasureOccurrence of radiographically identified vertebral fracture during
the year following an incident vertebral fracture.ResultsSubjects were a mean age of 74 years and had a mean of 28 years since
menopause. The cumulative incidence of new vertebral fractures in the first
year was 6.6%. Presence of 1 or more vertebral fractures at baseline increased
risk of sustaining a vertebral fracture by 5-fold during the initial year
of the study compared with the incidence in subjects without prevalent vertebral
fractures at baseline (relative risk [RR], 5.1; 95% confidence interval [CI],
3.1-8.4; P<.001). Among the 381 participants who
developed an incident vertebral fracture, the incidence of a new vertebral
fracture in the subsequent year was 19.2% (95% CI, 13.6%-24.8%). This risk
was also increased in the presence of prevalent vertebral fractures (RR, 9.3;
95% CI, 1.2-71.6; P = .03).ConclusionOur data indicate that women who develop a vertebral fracture are at
substantial risk for additional fracture within the next year.read more
Citations
More filters
Journal ArticleDOI
Scottish Intercollegiate Guidelines Network
Sara Twaddle,Safia Qureshi +1 more
TL;DR: This guideline has been assessed for its likely impact on the six equality groups defined by age, disability, gender, race, religion/belief, and sexual orientation.
Journal ArticleDOI
Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA).
E Hernlund,Axel Svedbom,M Ivergard,Juliet E. Compston,Cyrus Cooper,Cyrus Cooper,J Stenmark,Eugene V. McCloskey,Bengt Jönsson,John A. Kanis +9 more
TL;DR: In spite of the high social and economic cost of osteoporosis, a substantial treatment gap and projected increase of the economic burden driven by the aging populations, the use of pharmacological interventions to prevent fractures has decreased in recent years, suggesting that a change in healthcare policy is warranted.
Journal Article
KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD)
Journal ArticleDOI
2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary
Alexandra Papaioannou,Suzanne N Morin,Angela M. Cheung,Stephanie A. Atkinson,Jacques P. Brown,Sidney Feldman,David A. Hanley,Anthony B. Hodsman,Sophie A. Jamal,Stephanie M. Kaiser,Brent Kvern,Kerry Siminoski,William D. Leslie +12 more
TL;DR: There has been a paradigm shift in the prevention and treatment of osteoporosis and fractures, and the focus now is on preventing fragility fractures and their negative effects.
Journal ArticleDOI
The Effects of Strontium Ranelate on the Risk of Vertebral Fracture in Women with Postmenopausal Osteoporosis
Pierre J. Meunier,Christian Roux,Ego Seeman,Sergio Ortolani,J. Badurski,Tim D. Spector,J. Cannata,Adam Balogh,EM Lemmel,S. Pors-Nielsen,René Rizzoli,Harry K. Genant,Jean-Yves Reginster +12 more
TL;DR: Treatment of postmenopausal osteoporosis with strontium ranelate leads to early and sustained reductions in the risk of vertebral fractures.
References
More filters
Journal ArticleDOI
Effects of Risedronate Treatment on Vertebral and Nonvertebral Fractures in Women With Postmenopausal Osteoporosis: A Randomized Controlled Trial
Steven T. Harris,Nelson B. Watts,Harry K. Genant,Clark D. McKeever,Thomas N. Hangartner,Michael Keller,Charles H. Chesnut,Jacques P. Brown,Erik Fink Eriksen,Mohammad S. Hoseyni,Douglas Wayne Axelrod,Paul D. Miller +11 more
TL;DR: Risedronate, a potent bisphosphonate, has been shown to be effective in the treatment of Paget disease of bone and other metabolic bone diseases, but, to the knowledge, it has not been evaluated in this article.
Journal ArticleDOI
Patients with Prior Fractures Have an Increased Risk of Future Fractures: A Summary of the Literature and Statistical Synthesis
TL;DR: It is concluded that history of prior fracture at any site is an important risk factor for future fractures and patients with a history of Prior fracture should receive further evaluation for osteoporosis and fracture risk.
Journal ArticleDOI
Randomized trial of the effects of risedronate on vertebral fractures in women with established postmenopausal osteoporosis
Jean-Yves Reginster,Helmut W. Minne,Ole Helmer Sørensen,M Hooper,C Roux,M. L. Brandi,B. Lund,D. Ethgen,S Pack,I Roumagnac,Richard Eastell +10 more
TL;DR: Risedronate 5 mg provides effective and well-tolerated therapy for severe postmenopausal osteoporosis, reducing the incidence of vertebral fractures and improving bone density in women with established disease.
Journal ArticleDOI
Incidence of clinically diagnosed vertebral fractures: a population-based study in Rochester, Minnesota, 1985-1989.
TL;DR: Investigation of vertebral fractures in Rochester, Minnesota found that fractures following moderate trauma were higher in women than in men and rose steeply with age in both genders, while fractures following severe trauma were more frequent in men, and their incidence increased less with age.
Journal ArticleDOI
Pre-Existing Fractures and Bone Mass Predict Vertebral Fracture Incidence in Women
TL;DR: Combining information about bone mass and prevalent fracture appears to be better for predicting new fractures than either variable alone and Physicians can use these risk factors to identify patients at greatest risk for new fractures.