Open AccessJournal Article
KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD)
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This article is published in Kidney International.The article was published on 2009-08-01 and is currently open access. It has received 1723 citations till now. The article focuses on the topics: Chronic kidney disease-mineral and bone disorder & Guideline.read more
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Journal ArticleDOI
KDIGO clinical practice guideline for the care of kidney transplant recipients: a summary
Bertram L. Kasiske,Martin Zeier,Jeremy R. Chapman,Jonathan C. Craig,Henrik Ekberg,Catherine A. Garvey,Michael Green,Vivekanand Jha,Michelle A. Josephson,Bryce A. Kiberd,Henri Kreis,Ruth A. McDonald,John M. Newmann,Gregorio T. Obrador,Flavio Vincenti,Michael Cheung,Amy Earley,Gowri Raman,Samuel A Abariga,Martin Wagner,Ethan M Balk +20 more
TL;DR: The guideline makes recommendations for immunosuppression and graft monitoring, as well as prevention and treatment of infection, cardiovascular disease, malignancy, and other complications that are common in kidney transplant recipients, including hematological and bone disorders.
Journal ArticleDOI
Chronic kidney disease and cardiovascular risk: epidemiology, mechanisms, and prevention.
Ron T. Gansevoort,Ricardo Correa-Rotter,Brenda R. Hemmelgarn,Tazeen H. Jafar,Hiddo J.L. Heerspink,Johannes F.E. Mann,Kunihiro Matsushita,Chi Pang Wen +7 more
TL;DR: The epidemiology and pathophysiological mechanisms of cardiovascular risk in patients with chronic kidney disease are discussed, and methods of prevention are discussed.
Journal ArticleDOI
KDOQI US Commentary on the 2012 KDIGO Clinical Practice Guideline for the Evaluation and Management of CKD
Lesley A. Inker,Brad C. Astor,Chester H. Fox,Tamara Isakova,James P. Lash,Carmen A. Peralta,Manjula Kurella Tamura,Harold I. Feldman +7 more
TL;DR: The National Kidney Foundation-KDOQI guideline for evaluation, classification, and stratification of chronic kidney disease (CKD) was published in 2002 as mentioned in this paper, but concerns and criticisms arose as new evidence became available since the publication of the original guidelines.
Journal ArticleDOI
Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.
TL;DR: The structure of the liganded VDR/RXR complex was recently characterized using cryoelectron microscopy, X-ray scattering, and hydrogen deuterium exchange, which will result in a more complete understanding of VDR coactivator interactions, thus facilitating cell and gene specific clinical applications.
Journal ArticleDOI
Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis
Evolve Trial Investigators,Glenn M. Chertow,Geoffrey A. Block,Ricardo Correa-Rotter,Tilman B. Drüeke,J. Floege,William G. Goodman,Charles A. Herzog,Yumi Kubo,Gérard M. London,Kenneth W. Mahaffey,Mix Tc,Sharon M. Moe,Marie-Louise Trotman,David C. Wheeler,Patrick S. Parfrey +15 more
TL;DR: In an unadjusted intention-to-treat analysis, cinacalcet did not significantly reduce the risk of death or major cardiovascular events in patients with moderate- to-severe secondary hyperparathyroidism who were undergoing dialysis.
References
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Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial
Jacques E. Rossouw,Garnet L. Anderson,Ross L. Prentice,Andrea Z. LaCroix,Charles Kooperberg,Marcia L. Stefanick,Rebecca D. Jackson,Shirley A.A. Beresford,Barbara V. Howard,Karen C. Johnson,Jane Morley Kotchen,Judith K. Ockene +11 more
TL;DR: Overall health risks exceeded benefits from use of combined estrogen plus progestin for an average 5.2-year follow-up among healthy postmenopausal US women, and the results indicate that this regimen should not be initiated or continued for primary prevention of CHD.
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Vitamin D Deficiency
TL;DR: The role of vitamin D in skeletal and nonskeletal health is considered and strategies for the prevention and treatment ofitamin D deficiency are suggested.
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Grading quality of evidence and strength of recommendations.
David C. Atkins,Dana Best,Peter A. Briss,Martin P Eccles,Yngve Falck-Ytter,Signe Flottorp,Gordon H. Guyatt,Robin Harbour,Margaret C Haugh,David Henry,Suzanne Hill,Roman Jaeschke,Gillian Leng,Alessandro Liberati,Nicola Magrini,James Mason,Philippa Middleton,Jacek Mrukowicz,Dianne L. O'Connell,Andrew D Oxman,Bob Phillips,Holger J. Schünemann,Tessa Tan-Torres Edejer,H. Varonen,Gunn Elisabeth Vist,John W Williams,Stephanie Zaza +26 more
TL;DR: A system for grading the quality of evidence and the strength of recommendations that can be applied across a wide range of interventions and contexts is developed, and a summary of the approach from the perspective of a guideline user is presented.
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Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial
Garnet L. Anderson,Marian C. Limacher,Annlouise R. Assaf,Tamsen Bassford,Shirley A.A. Beresford,Henry R. Black,Denise E. Bonds,Robert L. Brunner,Robert G. Brzyski,Bette J. Caan,Rowan T. Chlebowski,J. David Curb,Margery Gass,Jennifer Hays,Gerardo Heiss,Susan L. Hendrix,Barbara V. Howard,Judith Hsia,F. Allan Hubbell,Rebecca D. Jackson,Karen C. Johnson,Howard L. Judd,Jane Morley Kotchen,Lewis H. Kuller,Andrea Z. LaCroix,Dorothy S. Lane,Robert Langer,Norman L. Lasser,Cora E. Lewis,JoAnn E. Manson,Karen L. Margolis,Judith K. Ockene,Mary Jo O'Sullivan,Lawrence S. Phillips,Ross L. Prentice,Cheryl Ritenbaugh,John A Robbins,Jacques E. Rossouw,Gloria E. Sarto,Marcia L. Stefanick,Linda Van Horn,Jean Wactawski-Wende,Robert B. Wallace,Sylvia Wassertheil-Smoller +43 more
TL;DR: The use of conjugated equine estrogen (CEE) increases the risk of stroke, decreases therisk of hip fracture, and does not affect CHD incidence in postmenopausal women with prior hysterectomy over an average of 6.8 years, indicating no overall benefit.
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Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis.
Robert M. Neer,Claude D. Arnaud,Jose R. Zanchetta,Richard L. Prince,Gregory A Gaich,Jean-Yves Reginster,Anthony B. Hodsman,Erik Fink Eriksen,Sophia Ish-Shalom,Harry K. Genant,Ouhong Wang,Bruce H. Mitlak +11 more
TL;DR: Treatment of postmenopausal osteoporosis with parathyroid hormone decreases the risk of vertebral and nonvertebral fractures; increases vertebral, femoral, and total-body bone mineral density; and is well tolerated.
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