Risk of Thyroid Cancer After Exposure to 131I in Childhood
Elisabeth Cardis,Ausrele Kesminiene,Victor K. Ivanov,Irina V Malakhova,Yoshisada Shibata,Valeryi Khrouch,Vladimir Drozdovitch,Evaldas Maceika,I. A. Zvonova,Oleg Vlassov,André Bouville,Guennadi Goulko,Masaharu Hoshi,Alexander Abrosimov,Jadvyga Anoshko,Larisa Astakhova,Sergey Chekin,Evgenyi Demidchik,Rosaria Galanti,Masahiro Ito,Elena Korobova,Evgenyi Lushnikov,M.A. Maksioutov,Vladimir Masyakin,Alexander Nerovnia,Vladimir Parshin,Evgenyi Parshkov,Nikolay N Piliptsevich,Aldo Pinchera,Semyon M Polyakov,Nina Shabeka,Eero Suonio,Vanessa Tenet,Anatoli F. Tsyb,Shunichi Yamashita,Dillwyn Williams +35 more
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TLDR
Stable iodine supplementation in iodine-deficient populations may substantially reduce the risk of thyroid cancer related to radioactive iodines in case of exposure to radioactive iodine in childhood that may occur after radiation accidents or during medical diagnostic and therapeutic procedures.Abstract:
relationship was observed up to 1.5 – 2 Gy. The risk of radiation-related thyroid cancer was three times higher in iodine-defi cient areas (relative risk [RR]= 3.2, 95% CI = 1.9 to 5.5) than elsewhere. Administration of potassium iodide as a dietary supplement reduced this risk of radiation-related thyroid cancer by a factor of 3 (RR = 0.34, 95% CI = 0.1 to 0.9, for consumption of potassium iodide versus no consumption). Conclusion: Exposure to 131 I in childhood is associated with an increased risk of thyroid cancer. Both iodine defi ciency and iodine supplementation appear to modify this risk. These results have important public health implications: stable iodine supplementation in iodine-defi cient populations may substantially reduce the risk of thyroid cancer related to radioactive iodines in case of exposure to radioactive iodines in childhood that may occur after radiation accidents or during medical diagnostic and therapeutic procedures. [J Natl Cancer Inst 2005;97:724 – 32]read more
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References
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TL;DR: This annex is aimed at providing a sound basis for conclusions regarding the number of significant radiation accidents that have occurred, the corresponding levels of radiation exposures and numbers of deaths and injuries, and the general trends for various practices, in the context of the Committee's overall evaluations of the levels and effects of exposure to ionizing radiation.
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Elaine Ron,Jay H. Lubin,Roy E. Shore,Kiyohiko Mabuchi,Baruch Modan,Linda M. Pottern,Arthur B. Schneider,Margaret A. Tucker,John D. Boice +8 more
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TL;DR: While excess rates for radiation-related cancers increase throughout the study period, a new finding is that relative risks decline with increasing attained age, as well as being highest for those exposed as children as noted previously.
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TL;DR: Variations in the risk of those tumours between different countries and different ethnic groups provide important information on the relative importance of environmental and genetic factors in their aetiology.
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