Rivastigmine attenuates the Alzheimer's disease related protein degradation and apoptotic neuronal death signalling.
Parul Gupta,Parul Gupta,Shubhangini Tiwari,Abhishek Singh,Abhishek Singh,Amit Pal,Amit Mishra,Sarika Singh,Sarika Singh +8 more
TLDR
In this paper, the effect of rivastigmine on protein aggregation and degradation related mechanisms employing streptozotocin (STZ) induced experimental rat model was evaluated.Citations
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4-Phenylbutyrate Mitigates the Motor Impairment and Dopaminergic Neuronal Death During Parkinson’s Disease Pathology via Targeting VDAC1 Mediated Mitochondrial Function and Astrocytes Activation
S. Tiwari,Parul Gupta,Ajay K. Singh,Swati Chaturvedi,Mohammad Wahajuddin,Amit Misra,Sarika Singh +6 more
TL;DR: Results suggest that 4PBA exerts broad-spectrum neuroprotective effects in PD animal model and exhibited significant protection against disease related oxidative stress and augmented nitrite levels.
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Guanabenz mitigates the neuropathological alterations and cell death in Alzheimer’s disease
TL;DR: Guanabenz treatment in both the experimental models showed significant protection against AD-specific behavioral and pathological indicators like AChE activity, tau phosphorylation, amyloid precursor protein, and memory retention, suggesting the panoptic protective effect of guanabenz on disease-related multiple degenerative markers and signaling.
Journal ArticleDOI
Benfotiamine protects against hypothalamic dysfunction in a STZ-induced model of neurodegeneration in rats.
Ruan Carlos Macêdo de Moraes,Gabriely Cristina Alves Lima,Camila Aparecida Errerias Fernandes Cardinali,Álisson de Carvalho Gonçalves,Guilherme Vannucchi Portari,Elvira Maria Guerra-Shinohara,Antoine Leboucher,José Donato Júnior,André Kleinridders,Andréa da Silva Torrão +9 more
TL;DR: In this paper , the effects of benfotiamine (BFT), a vitamin B1 analog that is being proposed as a therapeutical approach for AD-related cognitive alterations, which were induced by intracerebroventricular injection of streptozotocin (STZ).
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UBA52 Is Crucial in HSP90 Ubiquitylation and Neurodegenerative Signaling during Early Phase of Parkinson’s Disease
TL;DR: Data highlights the critical role of UBA52 in HSP90 ubiquitylation in parallel to its potential contribution to the modulation of various disease-related neurodegenerative signaling targets during the early phase of PD pathology.
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Endoplasmic Reticulum Stress-Related Signature for Predicting Prognosis and Immune Features in Hepatocellular Carcinoma
Genhao Zhang,Jian-rui Sun +1 more
TL;DR: A constructed four-gene risk model associated with ER stress can accurately predict survival outcomes in HCC patients, and the model's risk score is associated with the poor clinical classification.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
A new and rapid colorimetric determination of acetylcholinesterase activity.
TL;DR: A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions, etc., has been described and Kinetic constants determined by this system for erythrocyte eholinesterases are presented.
Journal ArticleDOI
Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain.
TL;DR: It is revealed that norepinephrine and dopamine are specifically localized in complex systems of neurons in the brain, a finding which lends support to the hypothesis that both amines may be neurotransmitters in the central nervous system.
Journal ArticleDOI
Oxidative stress and mitochondrial dysfunction in Alzheimer's disease
TL;DR: Evidence not only demonstrates the full spectrum of oxidative damage to neuronal macromolecules, but also reveals the occurrence of oxidative events early in the course of the disease and prior to the formation of the pathology, which support an important role of oxidative stress in AD.