Journal ArticleDOI
Role of the Ovum in Follicular Luteinization
TLDR
2 UV absorbent compounds, presumably steroids, were present in all ovarian venous plasma extracts of rabbits with ovectomized follicles and absent in all other extracts studied and the identification of these 2 compounds is in progress.Abstract:
To study the effect of the oocyte on the functional activity of granulosa cells, clear mature follicles of estrous rabbits were either punctured or ovectomized. Three days after treatment, granulosa cells of punctured follicles failed to show histological signs of luteinization. Six days after puncturing both oocytes and granulosa cells were degenerate histologically. Three days after ovectomy, granulosa cells showed histological characteristics of lutein cells. These lutein-like cells had disintegrated 8 days after ovectomy. The concentration of progesterone in the ovarian venous plasma 3 days after ovectomy was significantly higher than that present in the effluent plasma from ovaries with punctured follicles. The reverse was true for 20αhydroxy- 4-pregnen-3-one. Furthermore, 2 UV absorbent compounds, presumably steroids, were present in all ovarian venous plasma extracts of rabbits with ovectomized follicles and absent in all other extractsstudied. The identification of these 2 compounds is in progress...read more
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Book ChapterDOI
Development of Follicles in the Mammalian Ovary
TL;DR: This chapter discusses the development of follicles in the mammalian ovary, a complex, functional miniature organ arises from the handful of cells that constitute a simple primordial follicle, a structure so small that it is invisible at the lower magnifications of a light microscope.
Journal ArticleDOI
Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality
TL;DR: A new perspective on oocyte-CC interactions is improving knowledge of the processes regulating oocyte quality, which is likely to have a number of applications, including improving the efficiency of clinical IVM and thereby providing new options for the treatment of infertility.
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The bone morphogenetic protein system in mammalian reproduction
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Paracrine Actions Of Growth Differentiation Factor-9 in the Mammalian Ovary
TL;DR: In addition to playing a critical function as a growth and differentiation factor during early folliculogenesis, GDF-9 functions as an oocyte-secreted paracrine factor to regulate several key granulosa cell enzymes involved in cumulus expansion and maintenance of an optimal oocyte microenvironment, processes which are essential for normal ovulation, fertilization, and female reproduction.