Journal ArticleDOI
Salidroside protects cardiomyocyte against hypoxia-induced death: A HIF-1α-activated and VEGF-mediated pathway
TLDR
Data indicated that salidroside has protective effect against hypoxia-induced cardiomyocytes necrosis and apoptosis by increasing HIF-1alpha expression and subsequently up-regulating VEGF levels.About:
This article is published in European Journal of Pharmacology.The article was published on 2009-04-01. It has received 140 citations till now. The article focuses on the topics: Salidroside & Programmed cell death.read more
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Journal ArticleDOI
Adaptive response to oxidative stress: Bacteria, fungi, plants and animals.
TL;DR: The comparative approach is used to shed light on fundamental principles and mechanisms of regulation of antioxidant systems and to provide starting points from which to develop novel tools and hypothesis to facilitate meaningful investigations in the physiology and biochemistry of organismic response to oxidative stress.
Journal ArticleDOI
Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy.
TL;DR: Rhodiola rosea has robust traditional and pharmacological evidence of use in fatigue, and emerging evidence supporting cognition and mood, and it potentially attractive for use as a safe medication.
Journal ArticleDOI
Neuroprotective effects of salidroside against beta-amyloid-induced oxidative stress in SH-SY5Y human neuroblastoma cells.
TL;DR: Results suggest that salidroside has protective effects against Abeta(25-35)-induced oxidative stress, which might be a potential therapeutic agent for treating or preventing neurodegenerative diseases.
Journal ArticleDOI
Protective activity of salidroside against ethanol-induced gastric ulcer via the MAPK/NF-κB pathway in vivo and in vitro
Xiayun Chang,Fen Luo,Wenjiao Jiang,Lingpeng Zhu,Jin Gao,He He,Tingting Wei,Shilin Gong,Tianhua Yan +8 more
TL;DR: Investigation of the protective effect of Sal on ethanol-induced acute gastric ulcer and H2O2-induced gastric epithelial cell damage indicated that Sal inhibited the overproduction of pro-inflammatory cytokines and enhanced antioxidant activity.
Journal ArticleDOI
Salidroside attenuates beta amyloid-induced cognitive deficits via modulating oxidative stress and inflammatory mediators in rat hippocampus
Jia Zhang,Yan-feng Zhen,Pu-Bu-Ci-Ren,Ligang Song,Weina Kong,Tie-mei Shao,Xue Li,Xi-qing Chai +7 more
TL;DR: The results confirmed that Aβ1-40 peptide caused learning and memory deficits in rats and indicated that salidroside may have a protective effect against AD via modulating oxidative stress and inflammatory mediators.
References
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Journal ArticleDOI
Cell Death: Critical Control Points
TL;DR: The identification of critical control points in the cell death pathway has yielded fundamental insights for basic biology, as well as provided rational targets for new therapeutics.
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Vascular endothelial growth factor: basic science and clinical progress.
TL;DR: Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen in vitro and an angiogenic inducer in a variety of in vivo models and is implicated in intraocular neovascularization associated with diabetic retinopathy and age-related macular degeneration.
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Regulation of angiogenesis by hypoxia: role of the HIF system.
TL;DR: The role of HIF in developmental, adaptive and neoplastic angiogenesis, and the implications of oncogenic activation of extensive, physiologically interconnected hypoxia pathways for the tumor phenotype are discussed.
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Regulation of mammalian o2 homeostasis by hypoxia-inducible factor 1
TL;DR: HIF-1 appears to function as a master regulator of O2 homeostasis that plays essential roles in cellular and systemic physiology, development, and pathophysiology.
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Hypoxia-inducible factor-1 (HIF-1).
Qingdong Ke,Max Costa +1 more
TL;DR: Overexpression of HIF-1 has been found in various cancers, and targeting Hif-1 could represent a novel approach to cancer therapy.