Showing papers in "International Immunopharmacology in 2015"

TL;DR: Experimental evidence suggests that N. sativa extracts and TQ can potentially be employed in the development of effective therapeutic agents towards the regulation of immune reactions implicated in various infectious and non-infectious conditions including different types of allergy, autoimmunity, and cancer.

TL;DR: The data indicate that Tim-3 expression in NK cells can function as a prognostic biomarker in human lung adenocarcinoma and support thatTim-3 could be a new target for an immunotherapeutic strategy.

TL;DR: It is indicated that PD played a protective role in LPS-induced ALI and BEAS-2B cells and supported further study of PD as potential candidate for acute lung injury.

TL;DR: How the M2 phenotype mediates neuroprotective effects and the alternation of signaling cascades that control microglial phenotype after ischemic stroke are discussed.

TL;DR: Analytical results provided evidence that CDDO-Me could be a potential therapeutic candidate for treating LPS-induced ALI and had beneficial effects on the intervention for pathogenesis process at molecular, protein and transcriptional levels in vitro.

TL;DR: The results suggested that the inhibition of CCl4-induced inflammation by QE is due to its anti-oxidant activity and its ability to modulate the TLR2/TLR4 and MAPK/NF-κB signaling pathway.

TL;DR: It is suggested that gallic acid exerts potentially clinically useful anti-inflammatory effects mediated through the suppression of p65-NF-κB and IL-6/p-STAT3(Y705) activation.

TL;DR: Investigation of the protective effect of Sal on ethanol-induced acute gastric ulcer and H2O2-induced gastric epithelial cell damage indicated that Sal inhibited the overproduction of pro-inflammatory cytokines and enhanced antioxidant activity.

TL;DR: In vivo evidence is provided that kaempferol-mediated down-regulation of IKK and subsequent inhibition of NF-κB pathway activation may be associated with the reduction of hepatic inflammatory lesions, which is contributing to the improvement of insulin signaling defect in diabetes.

TL;DR: Results indicated that baicalein treatment markedly attenuated the damage of the mammary gland induced by LPS, suppressed the activity of myeloperoxidase (MPO) and the levels of tumor necrosis factor (TNF-α) and interleukin (IL-1β) in mice with LPS-induced mastitis, and suggested that baicalsein may have a potential prospect against mastitis.

TL;DR: The LPS-induced pro-inflammatory response in microglial cells can be markedly reduced by resveratrol, through IL-10 dependent up-regulation of SOCS3, requiring the JAK-STAT signaling pathway.

TL;DR: The results suggest that the SSD-mediated alleviation of DDP-induced nephrotoxicity was due to uncoupling of the ROS, P38, and JNK/NF-κB signalling pathways.

TL;DR: Current evidences suggest that inflammation can be both a cause and a consequence of VTE, and current anti-coagulation therapies are not well-equipped with the capacity to selectively inhibit inflammatory cells and pathways, and applying such inferences for selective pharmacological targeting of immune mediators in VTE is considered.

TL;DR: Piperine inhibits proliferation, by inducing G2/M cell cycle arrest, and the migration and invasion of HOS and U2OS cells, via increased expression of TIMP-1/-2 and down-regulation of MMP-2/-9 and these findings support further study of piperine as a promising therapeutic agent in the treatment of osteosarcoma.

TL;DR: It is shown that GLPS can protect hepatocyte injury induced by CCl4 through inhibiting lipid peroxidation, elevating antioxidant enzyme activity and suppressing apoptosis and immune inflammatory response.

TL;DR: The findings showed that PLD exerts beneficial effects on alloxan-induced liver injury in mice and its mechanism was investigated.

TL;DR: The findings suggest that the protective mechanism of EUL may be attributed partly to decreased production of proinflammatory cytokines through the regulating inflammation and redox status and support that use ofEUL is beneficial in the treatment of ALI.

TL;DR: Results indicate that 3',4'-dihydroxy-4-methoxydalbergione, 4- methoxYDalbergion, cearoin, and chrysin are the substances responsible for the anti-inflammatory activity of Nepalese propolis.

TL;DR: In vivo evaluation of BBR-loaded chitosan nanoparticles (CNs) showed higher anti-apoptosis activity in the treatment of OA compared with BBR solution at equivalent concentration and are potential therapeutic agents for OA.

TL;DR: The etiologies of CLDs are reviewed, the results of recent clinical trials of treatments for CLDs, and development of noninvasive methodologies for detecting CLDs and monitoring their progression toward HCC are reviewed.

TL;DR: Six lactic acid bacteria strains (four Lactobacillus plantarum strains and one each of Lactococcus lactis subsp. lactis and Pediococcus pentosaceus) have been isolated and shown to possess anti-oxidant activity are determined on human enterocyte-like HT-29-Luc and Caco-2 cells.

TL;DR: The results show that FA may serve as a novel drug in the treatment of these pathologies by inhibiting NADPH oxidase and NF-κB and subsequently decreasing VSMC oxidative stress and inflammation.

TL;DR: The results suggest that orally administered AIII may be metabolized to sarsasapogenin by gut microbiota, which may ameliorate inflammatory diseases such as colitis by inhibiting TLR4-NF-κB/MAPK signaling pathway and restoring Th17/Treg cell balance.

TL;DR: These findings suggest that ACh synthesized by T cells acts in an autocrine/paracrine fashion at AChRs on various immune cells to modulate immune function, thereby facilitating T cell development and/or differentiation, leading to immune modulation.

TL;DR: It is proposed that Aucubin may be a potential therapeutic choice in the treatment of OA due to its anti-inflammatory and chondroprotective features.

TL;DR: Curcumin and the quinocetone have similar effects in improving piglet growth, but dietary addition of 300 mg/kg or 400mg/kg curcumin was more effective than quinOCetone in improving intestinal mucosal barrier integrity, morphology, and immune status of weaned pigs.

TL;DR: The results indicate that sCP and CP possess antioxidative activity in vitro and in vivo, the activity of sCP is stronger than that of CP and sulfation modification can enhance the antioxidative and hepatoprotective activities of Codonopsis pilosula polysaccharide.

TL;DR: Several important molecular mechanisms involved in LPS-induced changes in pulmonary endothelial barrier function, including activation of myosin light chain kinase, RhoA and tyrosine kinases, and apoptosis of the endothelium lead to an elevation of lung endothelial permeability are summarized.

TL;DR: The results suggest that Tanshinone IIA suppresses renal fibrosis and inflammation via altering expression of TGF-β/Smad and NF-κB pathway in the remnant kidney, thus supporting the potential of Tanshine IIA as a new therapeutic agent for slowing the progression of CKD.

TL;DR: Treatment of linalool significantly attenuated CS-induced lung inflammation, coupled with inhibited the infiltration of inflammatory cells and TNF-α, IL-6,IL-1β, IL -8 and MCP-1 production and suppressed CS- induced NF-κB activation in a dose-dependent manner.