Journal ArticleDOI
Second-line therapy with levofloxacin after failure of treatment to eradicate helicobacter pylori infection: time trends in a Spanish Multicenter Study of 1000 patients
Javier P. Gisbert,Ángeles Pérez-Aisa,Fernando Bermejo,Manuel Castro-Fernandez,Pedro Almela,Jesús Barrio,Angel Cosme,Ines Modolell,Felipe Bory,Miguel Fernández-Bermejo,Luis Rodrigo,Jesús Ortuño,Pilar Sánchez-Pobre,Sam Khorrami,Alejandro Franco,A. Tomás,Iván Guerra,Eloisa Lamas,Julio Ponce,Xavier Calvet +19 more
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TLDR
Ten-day levofloxacin-containing therapy is an encouraging second-line strategy, providing a safe and simple alternative to quadruple therapy in patients whose previous standard triple therapy has failed and whether the efficacy of the regimen decreases with time is assessed.Abstract:
Background Second-line bismuth-containing quadruple therapy is complex and frequently induces adverse effects. A triple rescue regimen containing levofloxacin is a potential alternative; however, resistance to quinolones is rapidly increasing. Aim To evaluate the efficacy and tolerability of a second-line triple-regimen-containing levofloxacin in patients whose Helicobacter pylori eradication treatment failed and to assess whether the efficacy of the regimen decreases with time. Design Prospective multicenter study. Patients In whom treatment with a regimen comprising a proton-pump inhibitor, clarithromycin, and amoxicillin had failed. Intervention Levofloxacin (500 mg bid), amoxicillin (1 g bid), and omeprazole (20 mg bid) for 10 days. Outcome Eradication was confirmed using the C-urea breath test 4 to 8 weeks after therapy. Compliance/tolerance: Compliance was determined through questioning and recovery of empty medication envelopes. Incidence of adverse effects was evaluated by means of a questionnaire. Results The study sample comprised 1000 consecutive patients (mean age, 49 ± 15 y, 42% men, 33% peptic ulcer) of whom 97% took all medications correctly. Per-protocol and intention-to-treat eradication rates were 75.1% (95% confidence interval, 72%-78%) and 73.8% (95% confidence interval, 71%-77%). Efficacy (intention-to-treat) was 76% in the year 2006, 68% in 2007, 70% in 2008, 76% in 2009, 74% in 2010, and 81% in 2011. In the multivariate analysis, none of the studied variables (including diagnosis and year of treatment) were associated with success of eradication. Adverse effects were reported in 20% of patients, most commonly nausea (7.9%), metallic taste (3.9%), myalgia (3.1%), and abdominal pain (2.9%). Conclusions Ten-day levofloxacin-containing therapy is an encouraging second-line strategy, providing a safe and simple alternative to quadruple therapy in patients whose previous standard triple therapy has failed. The efficacy of this regimen remains stable with time.read more
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Journal ArticleDOI
Probiotics in Helicobacter pylori eradication therapy: A systematic review and meta-analysis
TL;DR: The use of probiotics plus standard therapy was associated with an increase in the H. pylori eradication rate, and a reduction in adverse events resulting from treatment in the general population, however, this therapy did not improve patient compliance.
Journal ArticleDOI
Helicobacter pylori second-line rescue therapy with levofloxacin- and bismuth-containing quadruple therapy, after failure of standard triple or non-bismuth quadruple treatments
Javier P. Gisbert,Maurizio Romano,Antonietta Gerarda Gravina,P. Solís-Muñoz,Fernando Bermejo,Javier Molina-Infante,Manuel Castro-Fernandez,Juan Ortuño,Alfredo J. Lucendo,M..T. Herranz,Ines Modolell,F. del Castillo,J. Gomez,Jesus Barrio,Benito Velayos,Blas J. Gomez,Jose Luis Domínguez,Agnese Miranda,Marco Martorano,Alicia Algaba,M. Pabón,Teresa Angueira,Luis Fernández-Salazar,Alessandro Federico,Alicia C Marin,Adrian G. McNicholl +25 more
TL;DR: The most commonly used second‐line Helicobacter pylori eradication regimens are bismuth‐containing quadruple therapy and levofloxacin‐containing triple therapy, both offering suboptimal results.
Journal ArticleDOI
IV Conferencia Española de Consenso sobre el tratamiento de la infección por Helicobacter pylori
Javier P. Gisbert,Javier Molina-Infante,Javier Amador,Fernando Bermejo,Luis Bujanda,Xavier Calvet,Manuel Castro-Fernandez,Antonio Cuadrado-Lavín,J. Ignasi Elizalde,Emili Gené,Fernando Gomollón,Angel Lanas,Carlos Martín de Argila,Fermín Mearin,Miguel Montoro,Ángeles Pérez-Aisa,Emilio Pérez-Trallero,Adrian G. McNicholl +17 more
TL;DR: Este consenso establece un aumento de the exigencia en the eficacia oficial de los tratamientos recomendados, que deben alcanzar, o preferiblemente superar, el 90% de curacion al ser administrados de forma empirica.
Journal ArticleDOI
Treatment of Helicobacter pylori infection: Meeting the challenge of antimicrobial resistance
TL;DR: A comprehensive overview of current and emerging strategies in the treatment of H. pylori infection, focusing on the challenge of antimicrobial resistance is provided.
Journal ArticleDOI
A review of rescue regimens after clarithromycin-containing triple therapy failure (for Helicobacter pylori eradication)
TL;DR: The aim of this study is to systematically review the efficacy of the second-line rescue therapies after the failure of a first-line clarithromycin-containing regimen, and to link this information with the previous first- line treatment.
References
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Current concepts in the management of Helicobacter pylori infection - The Maastricht III Consensus Report
Peter Malfertheiner,Francis Mégraud,Colm O'Morain,Franco Bazzoli,Emad M. El-Omar,David Y. Graham,Richard H. Hunt,Theodore Rokkas,Nimish Vakil,Ernst J. Kuipers +9 more
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H pylori antibiotic resistance: prevalence, importance, and advances in testing
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Journal Article
Worldwide H. pylori antibiotic resistance: a systematic review
De Francesco,Floriana Giorgio,Cesare Hassan,Gianpiero Manes,L Vannella,Carmine Panella,Enzo Ierardi,Angelo Zullo +7 more
TL;DR: The worldwide H. pylori antibiotic resistance towards different antibiotics has increased, and such a phenomenon may affect therapeutic management in different countries.
Journal ArticleDOI
Systematic review and meta-analysis: levofloxacin-based rescue regimens after Helicobacter pylori treatment failure.
TL;DR: A quadruple therapy has been generally recommended as rescue regimen for Helicobacter pylori eradication failures.