Journal ArticleDOI
Selective increase of brain dopamine induced by gamma-hydroxybutyrate: study of the mechanism of action.
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This article showed that γ-hydroxybutyrate (γ-OH) produces a selective accumulation of brain DA not only in normal animals but also in reserpinized animals.Abstract:
— γ-Hydroxybutyrate (γ-OH) produces a selective accumulation of brain DA not only in normal animals but also in reserpinized animals. This is especially evident after the administration of DOPA; while in parallel experiments γ-OH does not influence significantly the amount of 5-HT present in brain after 5-HTP treatment.
γ-OH does not raise DA in rats after inhibition of tyrosine hydroxylase. The accumulation of brain DA is not due to inhibition of MAO or COMT activity.read more
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The gamma-hydroxybutyrate signalling system in brain: organization and functional implications.
TL;DR: It is presumed that, under pathological conditions (hepatic failure, alcoholic intoxication, succinic semialdehyde dehydrogenase defects), the rate of GHB synthesis or degradation in the peripheral organ is modified and induces increased GHB levels which could interfere with the normal brain mechanisms.
Journal ArticleDOI
Gamma-hydroxybutyrate: An emerging drug of abuse that causes physical dependence
Gantt P. Galloway,S.L. Frederick,Frank E. Staggers,Marco Gonzales,S. Alex Stalcup,David Smith +5 more
TL;DR: The neuropharmacology, potential therapeutic uses and acute adverse effects of GHB are reviewed, followed by a case series of eight people using GHB.
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gamma-Hydroxybutyric acid in the treatment of alcohol dependence: a double-blind study.
TL;DR: The effect of gamma-hydroxybutyric acid on alcohol consumption and alcohol craving in alcoholics was investigated in a randomized double-blind study versus placebo as discussed by the authors, where patients were treated as outpatients during a three month period either with gamma hydroxbutyrric acid (50 mg/kg/day, divided into three daily doses) or with placebo.
References
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TL;DR: It has now been possible to demonstrate that brain, adrenal medulla, and sympathetically innervated tissues contain a specific hydroxylase that catalyzes the conversion of L-tyrosine to dopa.
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A sensitive and specific fluorescence assay for tissue serotonin
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Metabolism of Epinephrine and Other Sympathomimetic Amines
TL;DR: This review will describe these newer developments in the metabolism and physiological disposition of catecholamine hormones and related compounds of therapeutic interest.
Journal Article
A sensitive assay of monoamine oxidase activity in vitro: application to heart and sympathetic ganglia
TL;DR: A sensitive method of measuring monoamine oxidase in vitro based on the rate of indoleacetic acid formation from tryptamine is described, particularly suited for studies on organs with low levels of enzyme activity, or on small samples of tissue, such as a sympathetic ganglion.