Journal ArticleDOI
Selenium Levels in Human Blood and Tissues in Health and in Disease
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TLDR
Significantly lower selenium values were observed in sera from cancer patients than from normal individuals, and higher values were generally observed in patients with primary neoplasms of the reticuloendothelial system.Abstract:
The levels of selenium in human sera and pancreatic, hepatic and synovial tissues were measured. An attempt was made to correlate the selenium level with certain disease states. Selenium was determined by nerutron activation analysis, using the 17.4 second half-life isotope 77mSe with a sensitivity of 2ppb. Serum-bound selenium was determined in normal individuals and individuals with various malignancies, and medical and surgical disorders. Tissue selenium was assayed in diseased and normal pancreases, livers, and synovial membranes. A wide variation was observed both in the serum selenium content of patients with a malignancy and in postmoren pancreatic and synovial showing histopathological changes. Significantly lower selenium values were observed in sera from cancer patients than from normal individuals. Higher values were generally observed in patients with primary neoplasms of the reticuloendothelial system. Higher tissue concentrations were obtained in synovia from patients with rheumatoid arthritis and in pancreatic tissues associated with histopathological changes.read more
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Journal ArticleDOI
Selenium in global food systems.
TL;DR: Low Se status is likely to contribute to morbidity and mortality due to infectious as well as chronic diseases, and increasing Se intakes in all parts of the world can be expected to reduce cancer rates.
Journal ArticleDOI
Prediagnostic serum selenium and risk of cancer.
Walter C. Willett,J. Steven Morris,Sara L. Pressel,James Taylor,B. Frank Polk,Meir J. Stampfer,Bernard Rosner,Kenneth. Schneider,Curtis G. Hames +8 more
TL;DR: The association between low selenium level and cancer was strongest for gastrointestinal and prostatic cancers and Serum levels of vitamins A and E compounded the effect of low Selenium.
Journal ArticleDOI
Selenium deficiency in total parenteral nutrition.
TL;DR: Evidence is added for the essentiality of Se in man and the need to consider Se supplementation in long- term TPN and the close association between erythrocyte Se and GSHPx activity withTPN and blood transfusion could indicate that for these patients ery throat Se was largely determined by Se from GSHpx.
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Rationale and Strategies for Chemoprevention of Cancer in Humans
TL;DR: It is concluded that chemoprevention offers excellent prospects as a means of reducing cancer incidence and among currently available agents, the retinoids possess the best combination of properties.
Journal ArticleDOI
Normal levels of trace elements in human blood plasma or serum
Jacques Versieck,Rita Cornelis +1 more
TL;DR: Much work remains to be done to establish the normal levels of most trace elements in blood plasma or serum of apparently healthy individuals, and the development of adequate measures for contamination control is the most important prerequisite.