Semi-parametric estimation of the binormal ROC curve for a continuous diagnostic test.
Tianxi Cai,Chaya S. Moskowitz +1 more
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This work proposes two new methods for estimating the intercept and slope parameters from a binormal ROC curve that assesses the accuracy of a continuous diagnostic test using a profile likelihood and a simple algorithm.Abstract:
SUMMARY Not until recently has much attention been given to deriving maximum likelihood methods for estimating the intercept and slope parameters from a binormal ROC curve that assesses the accuracy of a continuous diagnostic test. We propose two new methods for estimating these parameters. The first method uses the profile likelihood and a simple algorithm to produce fully efficient estimates. The second method is based on a pseudo-maximum likelihood that can easily accommodate adjusting for covariates that could affect the accuracy of the continuous test.read more
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Journal ArticleDOI
Receiver-Operating Characteristic Analysis for Evaluating Diagnostic Tests and Predictive Models
TL;DR: The measures of accuracy—sensitivity, specificity, and area under the curve (AUC)—that use the ROC curve are reviewed, and how these measures can be applied using the evaluation of a hypothetical new diagnostic test as an example are illustrated.
Journal ArticleDOI
MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients
Federico Cappuzzo,Pasi A. Jänne,Margaret Skokan,Giovanna Finocchiaro,Elisa Rossi,C. Ligorio,Paolo Andrea Zucali,Luigi Terracciano,Luca Toschi,Massimo Roncalli,Annarita Destro,Matteo Incarbone,Marco Alloisio,Armando Santoro,Marileila Varella-Garcia +14 more
TL;DR: In this article, the MET gene copy number was analyzed using FISH in two related non-small-cell lung cancer cell lines, one sensitive (HCC827) and one resistant to gefitinib therapy and in two different NSCLC patient populations.
Journal ArticleDOI
EGFR FISH assay predicts for response to cetuximab in chemotherapy refractory colorectal cancer patients
Federico Cappuzzo,Gaetano Finocchiaro,Elisa Rossi,Pasi A. Jänne,C. Carnaghi,Cesare Calandri,Katia Bencardino,C. Ligorio,Fortunato Ciardiello,Tiziana Pressiani,Annarita Destro,Massimo Roncalli,L. Crinò,Wilbur A. Franklin,Armando Santoro,M. Varella-Garcia +15 more
TL;DR: CRC patients with high EGFR gene copy number have an increased likelihood to respond to cetuximab therapy, and Prospective clinical trials with a careful standardization of assay conditions and pattern interpretation are urgently needed.
Journal ArticleDOI
Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients.
Federico Cappuzzo,Marileila Varella-Garcia,Gaetano Finocchiaro,Gaetano Finocchiaro,Margaret Skokan,Sujatha Gajapathy,C. Carnaghi,Lorenza Rimassa,Elisa Rossi,C. Ligorio,C. Ligorio,L. Di Tommaso,Alison J. Holmes,Luca Toschi,Giovanni Tallini,Annarita Destro,Massimo Roncalli,Armando Santoro,Pasi A. Jänne +18 more
TL;DR: KRAS mutations are associated with cetuximab failure in EGFR FISH+ mCRC, even if it does not preclude response, and the rarity of MET and IGF1R gene amplification suggests a marginal role in primary resistance.
Journal ArticleDOI
Diagnostic accuracy and receiver-operating characteristics curve analysis in surgical research and decision making.
TL;DR: The fundamental roles, suggested presentation, potential biases, and interpretation of ROC analysis in surgical research are discussed, and appropriate use may help identify the most appropriate cutoff value for clinical and surgical decision making and avoid confounding effects seen with subjective ratings.
References
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