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Open AccessJournal Article

Separation of lactic acid : Recent advances

Kailas L. Wasewar
- 01 Jan 2005 - 
- Vol. 19, Iss: 2, pp 159-172
TLDR
A short review of the development of recovery of lactic acid from fermentation broth can be found in this article, where the authors focus on the developments of recovery for lactic acids.
Abstract
Carboxylic acids are important commercial products. The requirements of carboxylic acids (lactic acid, citric acid, propionic acid etc.) are increasing every year. Therefore, it is important to have an efficient recovery method following the production of carboxylic acid. At present most of the manufacturers use the conventional method of recovery, which is the calcium hydroxide precipitation method. This method of recovery is expensive and unfriendly to the environment as it consumes lime and sulphuric acid and also produces a large quantity of calcium sulphate sludge as solid waste. It is, therefore, reasonable to look for other methods of recovery for carboxylic acid. Lactic acid is used in food, chemical and pharmaceutical fields, and a raw material for the production of biodegradable polylactic acid, both, substitutes for conventional plastic materials and new materials of specific uses, such as controlled drug delivery or artificial prostheses. This short review focuses on the developments of recovery of lactic acid from fermentation broth.

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Recovery of carboxylic acids produced by fermentation

TL;DR: In-situ removal of carboxylic acid by extraction during fermentation is the most popular approach, but recovery of the extractant can easily lead to waste inorganic salt formation, which counteracts the advantage of the in-Situ removal.
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Methylglyoxal Bypass Identified as Source of Chiral Contamination in l (+) and d (−)-lactate Fermentations by Recombinant Escherichia coli

TL;DR: Two new strains of Escherichia coli B were engineered for the production of lactate with no detectable chiral impurity, and both strains produced optically pure d(−)-lactate.
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