Serum Vitamin D Is Significantly Inversely Associated with Disease Severity in Caucasian Adults with Obstructive Sleep Apnea Syndrome.
Conor P Kerley,Conor P Kerley,Katrina Hutchinson,Kenneth Bolger,Aisling McGowan,John Faul,Liam Cormican +6 more
TLDR
There is evidence that 25(OH)D and OSAS are related, but the role, if any, of replenishment has not been investigated, and widespread vitamin D deficiency and insufficiency in a Caucasian, OSAS population is observed.Abstract:
STUDY OBJECTIVES To evaluate vitamin D (25(OH)D) levels in obstructive sleep apnea syndrome (OSAS) and possible relationships to OSAS severity, sleepiness, lung function, nocturnal heart rate (HR), and body composition. We also aimed to compare the 25(OH)D status of a subset of OSAS patients compared to controls matched for important determinants of both OSAS and vitamin D deficiency (VDD). METHODS This was a cross-sectional study conducted at an urban, clinical sleep medicine outpatient center. We recruited newly diagnosed, Caucasian adults who had recently undergone nocturnal polysomnography. We compared body mass index (BMI), body composition (bioelectrical impedance analysis), neck circumference, sleepiness (Epworth Sleepiness Scale), lung function, and vitamin D status (serum 25-hydrpoxyvitamin D (25(OH)D) across OSAS severity categories and non-OSAS subjects. Next, using a case-control design, we compared measures of serum 25(OH)D from OSAS cases to non-OSAS controls who were matched for age, gender, skin pigmentation, sleepiness, season, and BMI. RESULTS 106 adults (77 male; median age = 54.5; median BMI = 34.3 kg/m(2)) resident in Dublin, Ireland (latitude 53°N) were recruited and categorized as non-OSAS or mild/moderate/severe OSAS. 98% of OSAS cases had insufficient 25(OH)D (< 75 nmol/L), including 72% with VDD (< 50 nmol/L). 25(OH)D levels decreased with OSAS severity (P = 0.003). 25(OH)D was inversely correlated with BMI, percent body fat, AHI, and nocturnal HR. Subsequent multivariate regression analysis revealed that 25(OH)D was independently associated with both AHI (P = 0.016) and nocturnal HR (P = 0.0419). Our separate case-control study revealed that 25(OH)D was significantly lower in OSAS cases than matched, non-OSAS subjects (P = 0.001). CONCLUSIONS We observed widespread vitamin D deficiency and insufficiency in a Caucasian, OSAS population. There were significant, independent, inverse relationships between 25(OH)D and AHI as well as nocturnal HR, a known cardiovascular risk factor. Further, 25(OH)D was significantly lower in OSAS cases compared to matched, non-OSAS subjects. We provide evidence that 25(OH)D and OSAS are related, but the role, if any, of replenishment has not been investigated.read more
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Vitamin D supplementation and body fat mass: a systematic review and meta-analysis.
TL;DR: 25(OH)D level is inversely correlated with PFM but cholecalciferol supplementation had no effect on PFM, and subgroup and meta-regression analyses indicated that age, latitude, and longitude are not sources of heterogeneity.
Journal ArticleDOI
The interfaces between vitamin D, sleep and pain.
TL;DR: The supplementation of vitamin D associated with good sleep hygiene may have a therapeutic role, not only in sleep disorders but also in the prevention and treatment of chronic pain conditions.
Journal ArticleDOI
Obstructive sleep apnea and objective short sleep duration are independently associated with the risk of serum vitamin D deficiency.
Ronaldo D. Piovezan,Camila Hirotsu,Marcia C. Feres,Fátima Dumas Cintra,Monica L. Andersen,Sergio Tufik,Dalva Poyares +6 more
TL;DR: OSA and short sleep duration are independently associated with the risk of 25(OH)D deficiency in an adult population and age-related changes in vitamin D metabolism and the frequency of sleep disorders may be involved in these associations.
Journal ArticleDOI
Vitamin D and Sleep Regulation: Is there a Role for Vitamin D?
Fiammetta Romano,Giovanna Muscogiuri,Elea Di Benedetto,Volha V. Zhukouskaya,Luigi Barrea,Silvia Savastano,Annamaria Colao,Carolina Di Somma +7 more
TL;DR: Vitamin D has both a direct and an indirect role in the regulation of sleep, and there is still scant evidence to concretely support the role of vitamin D supplementation in the prevention or the treatment of sleep disturbances.
Journal ArticleDOI
The role of vitamin D in obstructive sleep apnoea syndrome.
TL;DR: Current knowledge on the association between OSAS and vitamin D levels is summarized and potential for use of vitamin D supplementation in OSAS patients as a means of reducing the incidence of cardiovascular disease is considered, a comorbidity common in both conditions.
References
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Vitamin D Deficiency
TL;DR: The role of vitamin D in skeletal and nonskeletal health is considered and strategies for the prevention and treatment ofitamin D deficiency are suggested.
Journal ArticleDOI
Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline
Michael F. Holick,Neil Binkley,Heike A. Bischoff-Ferrari,Catherine M. Gordon,David A. Hanley,Robert P. Heaney,M. Hassan Murad,Connie M. Weaver +7 more
TL;DR: Considering that vitamin D deficiency is very common in all age groups and that few foods contain vitamin D, the Task Force recommended supplementation at suggested daily intake and tolerable upper limit levels, depending on age and clinical circumstances.
Journal Article
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Michael F. Holick,Neil Binkley,Heike A. Bischoff-Ferrari,Catherine M. Gordon,David A. Hanley,Robert P. Heaney,M. Hassan Murad,Connie M. Weaver +7 more
TL;DR: The Task Force as discussed by the authors provided guidelines to clinicians for the evaluation, treatment, and prevention of vitamin D deficiency with an emphasis on the care of patients who are at risk for deficiency, based on systematic reviews of evidence and discussions during several conference calls and e-mail communications.
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The Validity and Practicality of Sun-Reactive Skin Types I Through VI
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